RESEARCH BASE

Search 3,721 documents across 34 fields — every claim tier-rated by evidence

3,721 Documents 34 Sections 43,625 Citations 34,852 Keywords Indexed 4 Evidence Tiers

3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.

3,271 results for "ion channels" — page 86 of 164

L_5_05 Verified Genetics & Origins

L_5_05 — Epigenetic Clocks: Measuring Biological Age

Epigenetic clocks are mathematical models that estimate biological age — the physiological age of an organism's cells and tissues — based on DNA methylation patterns at specific CpG sites (regions where a cytosine nucleo

epigenetic clock DNA methylation biological age Horvath clock Hannum clock GrimAge
L_5_03 Verified Genetics & Origins

L_5_03 — Pharmacogenomics and Ancestral Medicine

Pharmacogenomics — the study of how genetic variation influences individual responses to drugs — bridges genetics, pharmacology, and clinical medicine. Humans carry extensive polymorphism in genes encoding drug-metaboliz

pharmacogenomics CYP2D6 CYP2C_5_04 drug metabolism personalized medicine warfarin
L_5_16 Verified Genetics & Origins

L_5_16 — Archaeogenetics: Ancient DNA and the Human Past

Archaeogenetics — the extraction and analysis of DNA from ancient human, animal, and plant remains — has transformed our understanding of human history since the field's breakthrough in 2010. Advances in next-generation

archaeogenetics ancient DNA aDNA paleogenomics Svante Pääbo David Reich
L_5_08 Verified Genetics & Origins

L_5_08 — Ancient DNA from Sediments: Cave Dirt Genomics

One of the most revolutionary methodological advances in ancient DNA (aDNA) research has been the recovery of hominin DNA directly from cave sediments — without any bones or teeth. This technique, pioneered by Matthias M

sediment DNA environmental DNA eDNA cave sediment ancient DNA metagenomic
L_5_07 Verified Genetics & Origins

L_5_07 — Genetics of Speech and Language: Beyond FOXP2

Language is humanity's most distinctive cognitive ability — and identifying its genetic basis has been a central goal of human genetics and neuroscience since the discovery of the KE family and the FOXP2 gene. The KE fam

FOXP2 language genetics speech CNTNAP2 SRPX2 ATP2C2
Y_4_04 Verified Altered States

Y_4_04 — Entoptic Phenomena and Phosphene Patterns

This document examines Entoptic Phenomena and Phosphene Patterns, a topic within the Consciousness research area. Key areas of investigation include Defining Entoptic Phenomena, Phosphenes: Light from Within, Heinrich Kl

entoptic phenomena phosphene form constants Heinrich Klüver mescaline Lewis-Williams
Y_4_22 Credible Altered States

Y_4_22 — Hypnagogic & Hypnopompic States

Hypnagogia (the transitional state between wakefulness and sleep onset) and hypnopompia (the transition from sleep to waking) are naturally occurring altered states of consciousness experienced universally by humans. Cha

hypnagogia hypnopompia sleep onset phosphenes tetris effect sleep paralysis
Y_4_13 Verified Altered States

Y_4_13 — Collective Effervescence and Group Altered States

Collective effervescence — Émile Durkheim's term (The Elementary Forms of Religious Life, 1912) for the heightened emotional energy generated when people gather and act together in coordinated ritual — describes a group

collective effervescence Durkheim group ritual emotional contagion synchrony entrainment
Y_5_09 Credible Altered States

Y_5_09 — Firewalking: Altered States, Pain Override, and Ritual Confidence

Firewalking — the practice of walking barefoot over a bed of hot embers, coals, or heated stones — is one of the most dramatic and visually arresting ritual practices in world culture, documented across diverse tradition

firewalking fire ritual Anastenaria pain override Leidenfrost effect endorphins
Y_5_08 Credible Altered States

Y_5_08 — Sweat Lodge and Heat-Induced Altered States

The sweat lodge — and heat-induced altered states more broadly — represents one of the most ancient and geographically widespread methods of intentionally altering consciousness through controlled hyperthermia: sustained

sweat lodge inipi Lakota sauna banya heat therapy
Y_5_10 Credible Altered States

Y_5_10 — Extreme Fasting: Breatharian Claims, Autophagy, and Metabolic States

Extreme fasting — prolonged and severe caloric restriction or complete food abstinence — occupies a unique position at the intersection of contemplative/ascetic practice, metabolic science, and pseudoscientific extremism

fasting autophagy caloric restriction breatharianism inedia metabolic states
Y_5_14 Credible Altered States

Y_5_14 — Drumming and Rhythmic Entrainment: Percussive Paths to Trance

Drumming and rhythmic entrainment — the use of sustained, repetitive percussive sound to alter consciousness — is one of the oldest and most universal methods of inducing trance states across human cultures. From the fra

drumming rhythmic entrainment shamanic drumming theta waves Neher auditory driving
Y_2_16 Credible Altered States

Y_2_16 — Near-Death Experience Latest Research

Near-death experiences (NDEs) — the vivid, structured experiences reported by approximately 10–20% of cardiac arrest survivors (including out-of-body perception, tunnel experiences, life reviews, encounters with deceased

near-death experience NDE AWARE study Sam Parnia cardiac arrest consciousness
Y_2_01 Verified Altered States

Y_2_01 — NDEs, OBEs & Consciousness Studies

Modern consciousness research — NDEs in cardiac arrest patients, children's past-life memories, and DMT-induced entity encounters — produces data that intersects remarkably with ancient descriptions of death journeys, as

NDE OBE near-death experience out-of-body AWARE study Parnia
Y_2_07 Verified Altered States

Y_2_07 — Temporal Lobe Epilepsy and Religious Experience

Temporal lobe epilepsy (TLE) — seizures originating in the temporal lobes, which contain structures critical for memory (hippocampus), emotion (amygdala), and sensory-experiential processing — produces some of the most d

temporal lobe epilepsy TLE Geschwind syndrome ecstatic seizure Dostoevsky religious experience
Y_2_11 Verified Altered States

Y_2_11 — Déjà Vu and Anomalous Memory Experiences

Déjà vu — from the French "already seen" — is the subjective, compelling sensation that a present experience has been previously encountered, despite the experiencer's knowledge that the situation is objectively novel. F

déjà vu anomalous memory temporal lobe familiarity recollection dual-process theory
Y_3_19 Credible Altered States

Y_3_19 — Kundalini Scientific Research

Kundalini — described in Hindu and yogic traditions as a dormant spiritual energy coiled at the base of the spine that can be awakened through meditation, yoga, or spontaneously, rising through the chakra system to produ

kundalini kundalini awakening yoga energy shakti chakra
Y_3_11 Verified Altered States

Y_3_11 — Biofeedback and Neurofeedback

Biofeedback is the process of using real-time monitoring of physiological signals — heart rate, muscle tension, skin conductance, brainwave patterns — to train voluntary control over processes normally considered involun

biofeedback neurofeedback EEG biofeedback brain-computer interface operant conditioning alpha training
Y_3_10 Verified Altered States

Y_3_10 — Fasting, Asceticism, and Altered Consciousness

Fasting and ascetic practices — deliberate deprivation of food, sleep, comfort, or sensory input — have been used across virtually all religious and spiritual traditions to induce altered states of consciousness, visions

fasting asceticism altered consciousness vision quest starvation ketosis autophagy
Y_3_20 Credible Altered States

Y_3_20 — Enlightenment Neuroscience: Satori, Samadhi & Mystical States

Enlightenment — known as satori or kensho in Zen Buddhism, samadhi in Hindu yogic traditions, fana in Sufism, theosis in Eastern Orthodox Christianity, and unio mystica in the Western mystical tradition — refers to state

enlightenment satori samadhi mystical experience nondual awareness default mode network