RESEARCH BASE

Search 3,721 documents across 34 fields — every claim tier-rated by evidence

3,721 Documents 34 Sections 43,625 Citations 34,852 Keywords Indexed 4 Evidence Tiers

3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.

105 results for "disease adaptation" — page 4 of 6

Verified

INTERDOC_12 — The Denisovan Ghost Population Puzzle

In 2010, Svante Pääbo's team at the Max Planck Institute for Evolutionary Anthropology sequenced DNA from a tiny finger bone fragment found in Denisova Cave, Altai Mountains, Siberia, and discovered an entirely new homin

Denisovan Denisova Cave archaic hominin introgression ghost population EPAS1
ZB_4_10 Verified Ecology & Biology

ZB_4_10 — Cave Ecology: Life in Perpetual Darkness

Cave ecology (speleobiology) investigates life in subterranean environments — caves, groundwater aquifers, lava tubes, and interstitial spaces — habitats characterized by permanent darkness, near-constant temperature, hi

cave ecology speleobiology troglobite stygobite troglobite adaptations chemolithoautotrophy
ZB_4_15 Credible Ecology & Biology

ZB_4_15 — Urban Wildlife Genomics: Rapid Evolution in the Anthropocene City

Cities — covering only ~3% of Earth's land surface but housing >55% of humanity — are emerging as powerful natural laboratories for studying rapid evolution in real time. Urban wildlife genomics investigates how the extr

urban-evolution wildlife-genomics urban-adaptation heat-island pollution-adaptation urban-speciation
ZB_4_03 Verified Ecology & Biology

ZB_4_03 — Desert Biology and Xerophytes

Deserts — regions receiving <250 mm of annual precipitation — cover ~33% of Earth's land surface and harbor organisms with some of the most remarkable adaptations in biology. Desert organisms face extreme challenges: wat

desert ecology xerophyte arid adaptation CAM photosynthesis water conservation succulent
ZB_3_06 Verified Ecology & Biology

ZB_3_06 — Fire Ecology

Fire ecology studies fire as a natural ecological process — a fundamental disturbance agent that shapes vegetation structure, species composition, nutrient cycling, and landscape patterns across much of Earth's terrestri

fire ecology wildfire prescribed burn fire regime pyrophyte serotiny
ZC_4_04 Verified Social Science

ZC_4_04 — Medical Anthropology — Culture, Healing, and the Body

Medical anthropology — the study of how health, illness, healing, and the body are experienced, understood, and managed across cultures — is one of anthropology's most productive subfields, bridging biological and social

medical anthropology healing illness disease sickness culture
G_4_09 Verified Modern Frameworks

G_4_09 — Bioarchaeology and Forensic Anthropology: Reading the Dead

Bioarchaeology—the study of human remains from archaeological contexts—transforms skeletons from anonymous objects into biographical records of individual lives. Through stable isotope analysis of bone and tooth enamel,

bioarchaeology isotope analysis strontium carbon isotopes nitrogen isotopes oxygen isotopes
G_4_17 Verified Modern Frameworks

G_4_17 — Microbiome Archaeology — Ancient Gut and Soil Microbes

Microbiome archaeology — the extraction and analysis of ancient microbial communities from archaeological materials (dental calculus, coprolites, mummified remains, soil sediments, ceramics) — has emerged since ~2012 as

microbiome ancient microbiome dental calculus paleomicrobiology metagenomics coprolite
G_3_16 Credible Modern Frameworks

G_3_16 — Complexity Theory and Civilizational Collapse

Complexity theory — drawn from physics, mathematics, ecology, and information theory — provides a powerful framework for understanding why civilizations collapse: not as the result of a single catastrophic event, but as

complexity collapse civilization complex systems emergence resilience
O_1_15 Verified Earth Anomalies

O_1_15 — Urban Heat Islands

The urban heat island (UHI) effect — the phenomenon whereby urban areas experience significantly higher temperatures than surrounding rural landscapes — was first scientifically documented by amateur meteorologist Luke H

urban heat island UHI surface temperature impervious surfaces albedo anthropogenic heat
T_2_06 Verified Psychology & Social

T_2_06 — Health Psychology and Stress

Health psychology investigates how psychological, behavioral, and social factors influence health, illness, and healthcare — integrating biological and psychosocial perspectives within the biopsychosocial model (Engel, 1

health psychology stress psychoneuroimmunology fight-or-flight HPA axis cortisol
T_2_04 Verified Psychology & Social

T_2_04 — Positive Psychology & Wellbeing Science

Positive psychology — the scientific study of what makes life worth living — was formally launched by Martin Seligman in his 1998 APA presidential address, shifting psychology's traditional focus from pathology and dysfu

positive psychology Seligman flourishing PERMA flow Csikszentmihalyi
T_5_10 Credible Psychology & Social

T_5_10 — The Psychology of Money: Behavioral Economics, Financial Decision-Making, and Wealth Psychology

The psychology of money explores how cognitive biases, emotional responses, social pressures, and personality traits systematically distort financial decision-making — departing dramatically from the "rational economic a

psychology of money behavioral economics Kahneman Tversky prospect theory loss aversion
L_1_04 Verified Genetics & Origins

L_1_04 — Archaic Human Species Synthesis

The human evolutionary tree is far more complex than the older linear model suggested. Fossils, ancient DNA, and proteomics now show that Homo sapiens overlapped with several other hominin lineages, including Neanderthal

archaic humans Neanderthal Denisovan Homo floresiensis hobbit Homo luzonensis
L_1_07 Verified Genetics & Origins

L_1_07 — Genetic Bottlenecks, Founder Effects, and Toba

Genetic bottlenecks — dramatic reductions in population size that slash genetic diversity — and founder effects — the reduced variation carried by small colonizing groups — have profoundly shaped the genomes of species f

genetic bottleneck founder effect Toba catastrophe supervolcano effective population size Ashkenazi founder
L_1_08 Verified Genetics & Origins

L_1_08 — Denisovans — Archaic Hominin Deep Dive

Denisovans are an extinct group of archaic hominins identified primarily through ancient DNA analysis rather than traditional fossil morphology — making them history's first hominins to be discovered by genetics. In 2010

Denisovans Denisova Cave archaic hominin Homo denisova introgression admixture
L_1_16 Verified Genetics & Origins

L_1_16 — Denisovan Genetics and Legacy

The Denisovans — an extinct group of archaic humans first identified in 2010 from ancient DNA extracted from a finger bone fragment found in Denisova Cave, Altai Mountains, Siberia (~41,000 years old) — represent one of

denisovans denisova-cave ancient-dna introgression epas1 altitude-adaptation
L_4_16 Verified Genetics & Origins

L_4_16 — Ancient Pathogen Genomics: Disease DNA from the Archaeological Record

Ancient pathogen genomics — the recovery and analysis of microbial DNA from archaeological remains — has revolutionized understanding of historical pandemics and pathogen evolution. The field was transformed when Johanne

ancient-pathogen-genomics yersinia-pestis mycobacterium-tuberculosis paleomicrobiology ancient-dna pandemic-history
L_3_09 Verified Genetics & Origins

L_3_09 — HLA Diversity and Immune System Evolution

The Human Leukocyte Antigen (HLA) system — the human version of the Major Histocompatibility Complex (MHC) found in all jawed vertebrates — is the most polymorphic gene region in the entire human genome. Located on chrom

HLA MHC major histocompatibility complex immune diversity balancing selection antigen presentation
L_3_05 Verified Genetics & Origins

L_3_05 — Blood Type Genetics and the ABO System

Blood group genetics represents one of the earliest and most clinically important applications of Mendelian inheritance in human biology. Karl Landsteiner's discovery of the ABO blood group system (1900–1901) — which ear

blood type ABO system Rh factor Karl Landsteiner blood transfusion blood group antigens