RESEARCH BASE
Search 3,721 documents across 34 fields — every claim tier-rated by evidence
3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.
106 results for "immune genes" — page 3 of 6
Z_5_16 — Synthetic Minimal Genomes: Designing Life from First Principles
The construction of synthetic minimal genomes — chemically synthesized chromosomes containing only the genes essential for autonomous cellular life — represents one of the most audacious achievements in modern biology, d
Z_3_08 — Genetics of Taste and Smell
Taste and smell perception are profoundly shaped by genetics, with variation in chemosensory receptor genes producing dramatically different sensory worlds between individuals. The olfactory receptor (OR) gene family — d
Z_3_06 — Genetics of Circadian Rhythms
Circadian rhythms — endogenous ~24-hour oscillations in physiology and behavior — are generated by an intracellular transcription-translation feedback loop (TTFL) encoded by a set of core clock genes conserved across ani
Z_3_05 — Viral Integration and Endogenous Retroviruses
Approximately 8% of the human genome consists of human endogenous retroviruses (HERVs) — the remnants of ancient retroviral infections that integrated into germline cells and were subsequently inherited vertically like a
Z_2_10 — Genetics of Aging and Progeria
Aging — the progressive decline in physiological function leading to increased vulnerability to disease and death — has a substantial genetic component: twin studies estimate heritability of human lifespan at ~25–30% (He
Z_2_06 — Nutrigenomics and Diet-Gene Interactions
Nutrigenomics — the study of how genetic variation influences nutritional requirements, dietary responses, and disease susceptibility — and its complement nutrigenetics (how diet influences gene expression) represent a r
Z_2_11 — Genetics of Immunity and MHC Diversity
The major histocompatibility complex (MHC) — known as the human leukocyte antigen (HLA) system in humans — is the most polymorphic gene region in the human genome, encoding cell-surface glycoproteins essential for adapti
Z_2_05 — Gene Therapy: History and Progress
Gene therapy — the introduction, alteration, or replacement of genetic material within a patient's cells to treat or cure disease — has evolved from a speculative concept to an approved clinical reality over five decades
Z_1_08 — Transposons and Mobile Genetic Elements
Transposable elements (TEs, transposons) — segments of DNA that can move or copy themselves to new genomic locations — are among the most abundant and influential components of eukaryotic genomes. Discovered by Barbara M
Z_1_04 — Gene Expression and Regulation
Gene expression regulation — the molecular mechanisms controlling when, where, and how much each gene is active — is the central process that enables a single genome to produce ~200 distinct cell types, orchestrate embry
Z_4_21 — Autophagy Mechanisms
Autophagy (from Greek, "self-eating") is a fundamental cellular process by which eukaryotic cells degrade and recycle their own components — damaged organelles, protein aggregates, intracellular pathogens, and surplus cy
Z_4_01 — Human Microbiome, Gut-Brain Axis, and the Holobiont Concept
The human microbiome — the ~38 trillion microbial cells (bacteria, archaea, fungi, viruses) inhabiting the human body — constitutes a co-evolved ecosystem that profoundly influences health, immunity, metabolism, developm
K_4_12 — Noosphere — Teilhard de Chardin, Vernadsky, and the Thinking Layer
The noosphere ("sphere of mind") is a concept developed independently by Russian geochemist Vladimir Vernadsky and French paleontologist-priest Pierre Teilhard de Chardin in the 1920s, describing a layer of collective hu
K_5_17 — Neuroplasticity, Cortical Reorganization, and Brain Self-Repair
Neuroplasticity — the brain's ability to reorganize its structure, function, and connections in response to experience, injury, or environmental demand — has transformed neuroscience from a static model ("the adult brain
E_4_05 — Cyclical Destruction and Renewal
Nearly every human civilization has independently conceived of time not as a single arrow but as a wheel — creation, flourishing, decay, destruction, and rebirth cycling endlessly. The Hindu yuga system maps a 4.32-billi
E_1_08 — Ancient Supernovae and Their Cultural Impact
Supernovae — the explosive deaths of massive stars — are among the most energetic events in the universe, capable of briefly outshining entire galaxies. When they occur within our galaxy at distances of a few thousand li
ZG_2_02 — Pidgins, Creoles, and Language Contact Phenomena
Pidgins and creoles are languages born from contact between groups with no shared language — they offer a natural laboratory for studying how human linguistic capacity creates new grammatical systems under extreme condit
ZG_3_02 — FOXP2 and the Genetics of Language
FOXP2 (Forkhead Box Protein P2) is the first gene directly linked to human speech and language ability, located on chromosome 7q31 and encoding a transcription factor that regulates hundreds of downstream genes involved
Q_4_06 — Baryon Asymmetry and Matter-Antimatter
One of the deepest unsolved problems in physics is the baryon asymmetry of the universe — the observed predominance of matter over antimatter. For every ~10⁹ photons in the cosmic microwave background, there is approxima
Q_3_01 — The Fermi Paradox & Drake Equation
Enrico Fermi's 1950 lunch question — "Where is everybody?" — remains one of the deepest unanswered questions in science. The galaxy is ~13.6 billion years old, contains ~100–400 billion stars, and (as we now know from Ke
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