RESEARCH BASE

Search 3,721 documents across 34 fields — every claim tier-rated by evidence

3,721 Documents 34 Sections 43,625 Citations 34,852 Keywords Indexed 4 Evidence Tiers

3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.

149 results for "action potential" — page 3 of 8

Z_3_14 Verified Molecular Biology

Z_3_14 — Behavioral Genetics and the Genetics of Aggression

Behavioral genetics investigates the relative contributions of genetic and environmental factors to variation in behavior — including aggression, impulsivity, risk-taking, anxiety, sociability, and cognitive traits. Twin

behavioral genetics aggression MAOA warrior gene serotonin dopamine
Z_3_07 Verified Molecular Biology

Z_3_07 — Gene Drive Technology

Gene drives are genetic systems that bias their own inheritance to spread through a population at rates exceeding normal Mendelian expectations (~50% → ~99% transmission). Natural selfish genetic elements (transposons, m

gene drive CRISPR gene drive selfish genetic element meiotic drive super-Mendelian inheritance Anopheles
Z_3_15 Credible Molecular Biology

Z_3_15 — Genetics of Intelligence: Polygenicity, GWAS, and the Heritability Debate

The genetics of intelligence — attempts to identify the specific genetic variants that influence individual differences in cognitive ability — represents one of the most complex and contentious areas in human genetics. H

intelligence IQ GWAS polygenicity heritability educational attainment
Z_2_13 Verified Molecular Biology

Z_2_13 — Pharmacogenomics and Personalized Medicine

Pharmacogenomics — the study of how genetic variation influences drug response — is among the most clinically actionable applications of human genetics. Adverse drug reactions (ADRs) are the 4th–6th leading cause of deat

pharmacogenomics pharmacogenetics personalized medicine precision medicine CYP2D6 CYP2C_5_04
Z_2_03 Verified Molecular Biology

Z_2_03 — Pharmacogenomics & Ethnobotanical Genetics

Pharmacogenomics — the study of how genetic variation affects drug response — has revealed that enzymes governing drug metabolism, particularly the cytochrome P450 (CYP) superfamily, show extraordinary population-specifi

pharmacogenomics ethnobotany CYP2D6 cytochrome P450 drug metabolism traditional medicine
Z_2_18 Verified Molecular Biology

Z_2_18 — Pharmacogenomics and Precision Medicine

Pharmacogenomics — the study of how genetic variation affects individual responses to drugs — aims to replace the "one-size-fits-all" prescribing model with genotype-guided therapy, selecting the right drug at the right

pharmacogenomics precision-medicine drug-metabolism cyp450 warfarin adverse-drug-reactions
Z_2_09 Verified Molecular Biology

Z_2_09 — Mitochondrial Genetics and Diseases

Human mitochondrial DNA (mtDNA) is a 16,569-bp circular genome encoding 37 genes: 13 proteins (all subunits of the oxidative phosphorylation/OXPHOS complexes I, III, IV, and V), 22 transfer RNAs, and 2 ribosomal RNAs. Un

mitochondrial genetics mtDNA mitochondrial DNA mitochondrial disease oxidative phosphorylation OXPHOS
Z_1_12 Verified Molecular Biology

Z_1_12 — Genome Architecture and 3D Organization

The human genome — approximately 6.4 billion base pairs of DNA — is packed into a nucleus only ~6 μm in diameter. If stretched end-to-end, the DNA of a single human cell would extend about 2 meters, yet it is packaged an

genome architecture 3D genome chromatin organization topologically associating domains TADs chromosome territories
Z_4_16 Verified Molecular Biology

Z_4_16 — Phase Separation in Cell Biology: Membraneless Organelles and Biomolecular Condensates

Liquid-liquid phase separation (LLPS) is the biophysical process by which proteins and nucleic acids demix from the surrounding cytoplasm or nucleoplasm to form concentrated, membrane-free droplets called biomolecular co

phase separation biomolecular condensate membraneless organelle liquid-liquid phase separation LLPS intrinsically disordered protein
K_3_05 Credible Consciousness

K_3_05 — Extended Mind and Cognitive Extension

The extended mind thesis (EMT), proposed by Andy Clark and David Chalmers in their landmark 1998 paper "The Extended Mind," argues that cognitive processes need not be confined within the skull — external objects, tools,

extended mind cognitive extension Clark and Chalmers parity principle Otto's notebook scaffolded cognition
K_3_18 Verified Consciousness

K_3_18 — Bioelectricity and Consciousness Transitions

Conscious experience tracks specific patterns of bioelectric activity in neural tissue, and every clinically validated method of producing unconsciousness — general anesthesia, deep sleep, hypothermic circulatory arrest,

bioelectricity consciousness transitions anesthesia mechanism ion channels membrane potential neural decoherence
K_1_03 Verified Consciousness

K_1_03 — Free Energy Principle and Predictive Processing

The Free Energy Principle (FEP), developed by neuroscientist Karl Friston (2006-present), is one of the most ambitious theoretical frameworks in 21st-century science: it attempts to explain the EXISTENCE, BEHAVIOR, and C

free energy principle FEP Karl Friston predictive processing predictive coding active inference
K_1_11 Verified Consciousness

K_1_11 — Dualism: Mind-Body Problem Across Philosophy and Neuroscience

The mind-body problem — the question of how subjective mental experience (consciousness, thought, sensation, emotion) relates to the physical body (brain, nervous system, matter) — is arguably the oldest and most persist

dualism mind-body problem substance dualism property dualism Descartes Chalmers
K_4_13 Verified Consciousness

K_4_13 — Mirror Neurons and Social Cognition

Mirror neurons are a class of neurons, first discovered in the early 1990s in the premotor cortex (area F5) of macaque monkeys by Giacomo Rizzolatti, Vittorio Gallese, and colleagues at the University of Parma, that fire

mirror neuron social cognition empathy imitation action understanding premotor cortex
K_2_07 Speculative Consciousness

K_2_07 — Electromagnetic Theories of Consciousness

Electromagnetic (EM) field theories of consciousness propose that conscious experience arises from or is identical to the brain's endogenous electromagnetic field — the complex, time-varying EM field generated by the syn

electromagnetic consciousness EM field theory consciousness CEMI field theory McFadden Pockett synchronous oscillations
K_2_10 Verified Consciousness

K_2_10 — Neural Entrainment: External Rhythmic Brain Synchronization

Neural entrainment — the process by which rhythmic external stimuli (sound, light, tactile vibration, or electromagnetic fields) synchronize the timing of neural oscillations in the brain — is a well-established neurophy

neural entrainment brainwave entrainment auditory entrainment photic driving rhythmic stimulation neural oscillation
K_5_13 Credible Consciousness

K_5_13 — Integrated World Models: Bayesian Brain and Consciousness

The Bayesian brain hypothesis proposes that the brain is fundamentally a prediction machine — it constructs and maintains internal generative models of the world (including the body), uses these models to generate predic

Bayesian brain predictive processing predictive coding free energy principle Friston Helmholtz
E_3_22 Verified Cataclysms & Chronology

E_3_22 — Historic Mega-Earthquakes: Cascadia, New Madrid, and the Seismic Record

The seismic record of North America reveals two mega-earthquake systems that challenge the common assumption that destructive earthquakes are confined to well-known plate boundaries like the San Andreas Fault: the Cascad

mega-earthquake Cascadia New Madrid seismology subduction zone paleoseismology
E_2_12 Verified Cataclysms & Chronology

E_2_12 — Great Oxygenation Event

The Great Oxygenation Event (GOE) — approximately 2.4–2.1 billion years ago — was one of the most transformative events in Earth's history: the first permanent rise of free molecular oxygen (O₂) in the atmosphere, from n

Great Oxygenation Event GOE oxygen crisis cyanobacteria photosynthesis Paleoproterozoic
ZG_4_12 Verified Linguistics & Communication

ZG_4_12 — Second Language Acquisition: Interlanguage, Critical Period, and SLA

Second Language Acquisition (SLA) — the study of how people learn languages beyond their first (L1) — is a multidisciplinary field drawing on linguistics, psychology, cognitive science, and education. Central questions i

second language acquisition SLA interlanguage Selinker critical period Lenneberg