RESEARCH BASE

Search 3,721 documents across 34 fields — every claim tier-rated by evidence

3,721 Documents 34 Sections 43,625 Citations 34,852 Keywords Indexed 4 Evidence Tiers

3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.

555 results for "systems biology" — page 27 of 28

R_2_06 Verified Biology & Evolution

R_2_06 — Isbell Snake Detection Hypothesis

This document examines Isbell Snake Detection Hypothesis, a topic within the Biology Evolution research area. Key areas of investigation include Origin and Author, The Core Thesis, The Expanded Pulvinar. The analysis spa

Lynne Isbell snake detection theory primate vision pulvinar nucleus trichromatic vision Quan Van Le
R_2_11 Verified Biology & Evolution

R_2_11 — Convergent Evolution: Parallel Solutions Across Lineages

Convergent evolution — the independent origin of similar features in unrelated lineages — is one of the most striking patterns in the history of life, suggesting that natural selection repeatedly discovers the same "solu

convergent evolution parallel evolution analogy homoplasy camera eye echolocation
R_2_08 Verified Biology & Evolution

R_2_08 — Bipedalism — Why We Walk Upright and What It Cost Us

Bipedalism — habitual upright walking on two legs — is the defining characteristic of the hominin lineage, predating brain enlargement, tool use, and language by millions of years. The earliest evidence comes from Sahela

bipedalism human evolution Sahelanthropus Ardipithecus Laetoli footprints savanna hypothesis
R_2_15 Verified Biology & Evolution

R_2_15 — Neoteny and Heterochrony in Human Evolution

Heterochrony — evolutionary change in the timing or rate of developmental processes — is one of the most powerful mechanisms by which evolution generates morphological diversity without requiring new genes. [KEY FINDING]

neoteny heterochrony paedomorphosis peramorphosis developmental-timing skull-morphology
R_2_09 Credible Biology & Evolution

R_2_09 — Self-Domestication Hypothesis — Did Humans Tame Themselves?

The human self-domestication hypothesis proposes that Homo sapiens underwent a domestication process analogous to that of dogs, livestock, and Belyaev's experimentally domesticated foxes — but without an external domesti

self-domestication Brian Hare cranial globularization reduced brow ridge sexual dimorphism neural crest cells
R_1_11 Verified Biology & Evolution

R_1_11 — Extinction, Recovery, and Adaptive Radiation

The history of life is punctuated by mass extinction events — catastrophic biodiversity losses that eliminate >75% of species in geologically brief intervals — followed by recovery phases and adaptive radiations during w

mass extinction Big Five adaptive radiation recovery background extinction end-Permian
R_1_00 Biology & Evolution

R_1_00 — Origin Early Life: Subfolder Summary

R_1_08 Verified Biology & Evolution

R_1_08 — Photosynthesis — The Reaction That Made Complex Life Possible

Photosynthesis — the conversion of light energy into chemical energy — is arguably the most consequential biochemical innovation in Earth's history. Oxygenic photosynthesis, evolved by cyanobacteria approximately 2.4–3.0

photosynthesis Great Oxygenation Event cyanobacteria chloroplast endosymbiosis Lynn Margulis
R_1_10 Credible Biology & Evolution

R_1_10 — RNA World Hypothesis: The Origin of Life and Self-Replicating RNA

The RNA World hypothesis proposes that early life was based on RNA molecules that served as both genetic material and catalysts — before the emergence of DNA and proteins. This idea, named by Walter Gilbert in 1986, rest

RNA world ribozymes self-replicating RNA origin of life abiogenesis protocells
R_1_13 Verified Biology & Evolution

R_1_13 — Archaea: The Third Domain and Extremophilic Diversity

Archaea constitute the third domain of life — neither Bacteria nor Eukarya — recognized as a distinct lineage by Carl Woese and George Fox in 1977 through revolutionary 16S ribosomal RNA phylogenetic analysis. For decade

Archaea third domain Carl Woese extremophile thermophile halophile
R_1_01 Verified Biology & Evolution

R_1_01 — Abiogenesis & Origin of Life Theories

Abiogenesis — the emergence of life from non-living chemistry — remains one of the deepest unsolved problems in science. The oldest confirmed microfossils date to ~3.5 billion years ago (Pilbara, Western Australia), with

abiogenesis origin of life RNA world panspermia hydrothermal vents Miller-Urey
R_1_07 Verified Biology & Evolution

R_1_07 — Viruses as Evolutionary Drivers — Endogenous Retroviruses and Genomic Integration

Viruses are not merely disease agents — they are fundamental architects of evolution. The human genome contains approximately ~8% endogenous retroviral (ERV) sequences (~100,000 ERV fragments), meaning roughly eight time

virus retrovirus endogenous retrovirus ERV HERV viral DNA
R_1_03 Verified Biology & Evolution

R_1_03 — Mass Extinction Events

Life on Earth has endured at least five catastrophic mass extinctions in 540 million years, each eliminating 60–96% of all species. The "Big Five" are: End-Ordovician (~443 Mya, ~85% species lost), Late Devonian (~372 My

mass extinction Big Five Permian Cretaceous K-Pg Chicxulub
R_1_02 Verified Biology & Evolution

R_1_02 — The Cambrian Explosion

Between ~541 and ~520 million years ago, nearly ALL major animal body plans (phyla) appeared in the fossil record in an evolutionary "instant" — roughly 20 million years. Before this, life had been single-celled for ~3 b

Cambrian explosion animal phyla body plans Burgess Shale Chengjiang Ediacaran
R_1_06 Verified Biology & Evolution

R_1_06 — Symbiogenesis — Lynn Margulis and Cooperative Evolution

Symbiogenesis — the evolutionary origin of new organisms, organelles, or metabolic capabilities through the permanent merger of previously independent life forms — is one of the most consequential biological discoveries

symbiogenesis Lynn Margulis endosymbiosis mitochondria chloroplasts serial endosymbiotic theory
R_1_15 Verified Biology & Evolution

R_1_15 — The Chirality Problem: Why Life Uses Left-Handed Amino Acids

One of the deepest unsolved problems in the origin of life is homochirality — the fact that all known life on Earth uses almost exclusively L-amino acids (left-handed) for proteins and D-sugars (right-handed) for nucleic

chirality homochirality amino acids L-amino acids D-sugars stereochemistry
R_1_14 Verified Biology & Evolution

R_1_14 — Biofilms: Microbial Communities, Quorum Sensing, and Cooperation

Biofilms are structured communities of microorganisms — bacteria, archaea, fungi, and algae — attached to surfaces and embedded in a self-produced matrix of extracellular polymeric substances (EPS): polysaccharides, prot

biofilm quorum sensing extracellular polymeric substance EPS microbial community antibiotic resistance
R_1_09 Verified Biology & Evolution

R_1_09 — The Great Oxidation Event: Oxygen, Cyanobacteria, and Earth's Atmospheric Transformation

The Great Oxidation Event (GOE), occurring approximately 2.4–2.1 billion years ago during the Paleoproterozoic, was the most dramatic chemical transformation in Earth's history — atmospheric oxygen rose from trace levels

Great Oxidation Event GOE cyanobacteria oxygenic photosynthesis atmospheric oxygen banded iron formations
S_4_18 Credible Future Technology

S_4_18 — Space Habitats & In-Situ Resource Utilization (ISRU)

Space habitation beyond low Earth orbit requires solving two fundamental challenges: creating livable enclosed environments and manufacturing essential materials from local resources rather than launching everything from

space-habitats isru in-situ-resource-utilization oneill-cylinder mars-architecture lunar-regolith
S_4_17 Verified Future Technology

S_4_17 — Space Habitats & In-Situ Resource Utilization (ISRU): Off-World Settlement Engineering

Space habitats and In-Situ Resource Utilization (ISRU) — the extraction and processing of local materials (regolith, water ice, atmospheric gases) to support human presence beyond Earth — constitute the engineering found

space habitat ISRU O'Neill cylinder Mars settlement lunar base radiation shielding