RESEARCH BASE

Search 3,721 documents across 34 fields — every claim tier-rated by evidence

3,721 Documents 34 Sections 43,625 Citations 34,852 Keywords Indexed 4 Evidence Tiers

3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.

1,723 results for "System 2" — page 21 of 87

ZD_4_10 Credible Information & Computation

ZD_4_10 — Complexity Theory in Biology — Kauffman, Wolfram, Edge of Chaos

The application of complexity theory to biology — the study of how complex, adaptive, self-organizing structures and behaviors emerge in living systems from the interactions of simpler components — has been one of the mo

complexity edge of chaos self-organization emergence Kauffman Wolfram
ZD_4_04 Verified Information & Computation

ZD_4_04 — Mathematical Modeling and Simulation

Mathematical modeling — the art and science of translating real-world phenomena into mathematical language — is how scientists bridge theory and observation. A mathematical model is a simplified mathematical representati

mathematical modeling simulation differential equation model agent-based model compartmental model SIR model
L_1_01 Verified Genetics & Origins

L_1_01 — Ancient DNA & Population Genetics

Modern paleogenomics has shown that human evolution was shaped by interbreeding, population structure, and repeated demographic turnover rather than a simple single-line progression. Ancient DNA revealed previously unkno

Denisovans Denisova Cave Svante Pääbo Nobel Prize ancient DNA aDNA
L_1_05 Verified Genetics & Origins

L_1_05 — Human Skin Color — Evolution, Latitude, and Cultural Significance

Human skin color is one of the most visible and most misunderstood traits in our species. The variation is primarily a product of natural selection balancing two competing needs: protection of folate (vitamin B9) from UV

skin pigmentation SLC24A5 MC1R vitamin D folate UV radiation
L_1_13 Verified Genetics & Origins

L_1_13 — Homo Naledi: Underground Burial and Primitive Morphology

Homo naledi is one of the most unexpected and controversial hominin discoveries of the 21st century. Announced in 2015 by Lee Berger (University of the Witwatersrand) and an international team, the species was recovered

Homo naledi Rising Star Dinaledi Chamber Lee Berger primitive morphology hominin
L_4_05 Verified Genetics & Origins

L_4_05 — Paleogenomics Methods and Ancient DNA

Paleogenomics — the study of ancient genomes — has transformed archaeology, anthropology, and evolutionary biology over the past two decades, recognized by the 2022 Nobel Prize in Physiology or Medicine awarded to Svante

paleogenomics ancient DNA aDNA ancient DNA extraction petrous bone DNA degradation
L_4_01 Verified Genetics & Origins

L_4_01 — Ancient DNA from Sediment — Environmental DNA Revolution

Environmental DNA (eDNA) recovery from sediments has revolutionized our ability to detect the presence of organisms — including ancient humans — without requiring the discovery of any bones, teeth, or artifacts. The land

environmental DNA eDNA sediment DNA Denisova Cave permafrost DNA metagenomic sequencing
L_4_09 Verified Genetics & Origins

L_4_09 — Selective Sweeps and Positive Selection in Humans

A selective sweep occurs when a beneficial allele rises rapidly in frequency under positive natural selection, carrying nearby linked variants along with it (genetic hitchhiking) and reducing genetic variation across the

selective sweep positive selection natural selection allele frequency hitchhiking extended haplotype homozygosity
L_4_10 Verified Genetics & Origins

L_4_10 — Sex Chromosome Evolution

Sex chromosomes — the genetic elements that determine biological sex in many organisms — represent one of the most remarkable stories in genome evolution. In mammals, the XX/XY system prevails: females have two X chromos

sex chromosome X chromosome Y chromosome sex determination SRY dosage compensation
L_4_08 Verified Genetics & Origins

L_4_08 — Genetic Genealogy and Forensic Genomics

Genetic genealogy — the use of DNA testing for genealogical purposes — has undergone an explosive expansion since the early 2000s, driven by direct-to-consumer (DTC) genetic testing companies (23andMe, AncestryDNA, MyHer

genetic genealogy forensic DNA DNA profiling STR SNP array direct-to-consumer genetic testing
L_3_16 Verified Genetics & Origins

L_3_16 — Genomic Imprinting & Evolutionary Conflict

Genomic imprinting — the epigenetic phenomenon in which a subset of genes (~100–200 in mammals) are expressed from only one parental allele, with the other allele silenced by DNA methylation and histone modification esta

genomic imprinting parent-of-origin expression epigenetics kinship theory parental conflict IGF2
L_3_06 Credible Genetics & Origins

L_3_06 — Genetics of Intelligence and Cognition

The genetics of intelligence — one of the most studied yet contentious areas in behavioral genetics — has established that cognitive ability, as measured by standardized tests, has a substantial heritable component (~50–

intelligence genetics cognitive ability IQ heritability GWAS intelligence polygenic score educational attainment
L_3_11 Verified Genetics & Origins

L_3_11 — Genetics of Taste and Dietary Adaptation

Taste perception — the ability to detect sweet, salty, sour, bitter, and umami (savory) stimuli — is mediated by genetically encoded receptor proteins whose variation across individuals and populations reflects evolution

taste genetics TAS2R_4_05 PTC PROP bitter taste umami
L_3_08 Verified Genetics & Origins

L_3_08 — Genetics of Skin, Hair, and Eye Color

Human pigmentation — skin, hair, and eye color — is one of the best-understood complex traits in human genetics, with a relatively modest number of genes explaining a large proportion of variation compared to most polyge

pigmentation genetics melanin eumelanin pheomelanin MC1R OCA2
L_5_10 Verified Genetics & Origins

L_5_10 — Neandertal Introgression: Which Genes and Why They Persisted

When modern humans (Homo sapiens) migrated out of Africa ~60,000-70,000 years ago and encountered Neanderthals (Homo neanderthalensis) in western Asia and Europe, the two species interbred — and the genetic legacy of tha

Neandertal introgression admixture adaptive introgression purifying selection immune genes
L_5_15 Verified Genetics & Origins

L_5_15 — Genetic Genealogy: DNA Ancestry Testing and Population History

Genetic genealogy — the use of DNA testing to determine relationships and ancestry — has revolutionized both personal genealogy and population genetics since the early 2000s. Three types of DNA analysis provide different

genetic genealogy DNA ancestry 23andMe haplogroup mtDNA Y-chromosome
L_5_03 Verified Genetics & Origins

L_5_03 — Pharmacogenomics and Ancestral Medicine

Pharmacogenomics — the study of how genetic variation influences individual responses to drugs — bridges genetics, pharmacology, and clinical medicine. Humans carry extensive polymorphism in genes encoding drug-metaboliz

pharmacogenomics CYP2D6 CYP2C_5_04 drug metabolism personalized medicine warfarin
L_5_06 Verified Genetics & Origins

L_5_06 — Genetic Adaptation to Disease: Malaria, Plague, TB

Infectious disease has been the most powerful selective force on the human genome throughout history. Pathogens — particularly malaria, plague, tuberculosis, smallpox, and cholera — have killed more humans than all other

natural selection disease adaptation malaria sickle cell G6PD Duffy antigen
L_5_13 Credible Genetics & Origins

L_5_13 — The Microbiome-Brain Axis: Gut Bacteria, Mood & Consciousness

The microbiome-gut-brain axis — bidirectional communication between the trillions of gut microorganisms and the central nervous system — has emerged as one of the most significant frontiers in neuroscience and consciousn

microbiome-brain-axis gut-brain-axis psychobiome vagus-nerve microbial-metabolites serotonin-gut
Y_4_08 Verified Altered States

Y_4_08 — Sleep Science — REM, NREM, and the Ancient Understanding of Sleep

Sleep science has undergone a revolution in the 21st century, fundamentally altering our understanding of why humans sleep. The landmark 2012 discovery of the glymphatic system by Maiken Nedergaard revealed that the brai

sleep REM NREM glymphatic system slow-wave sleep dreams