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398 results for "Cen Jianyong" — page 15 of 20

L_4_03 Genetics & Origins

L_4_03 — Genetic Clocks and Molecular Dating

The molecular clock — the concept that DNA and protein sequences accumulate mutations at approximately regular rates over time — provides a powerful tool for dating evolutionary divergences independently of the fossil re

molecular clock mutation rate molecular dating divergence time substitution rate neutral theory
L_4_09 Verified Genetics & Origins

L_4_09 — Selective Sweeps and Positive Selection in Humans

A selective sweep occurs when a beneficial allele rises rapidly in frequency under positive natural selection, carrying nearby linked variants along with it (genetic hitchhiking) and reducing genetic variation across the

selective sweep positive selection natural selection allele frequency hitchhiking extended haplotype homozygosity
L_4_15 Verified Genetics & Origins

L_4_15 — Y-Chromosome and mtDNA Mismatch Patterns in Human Populations

The Y chromosome (paternally inherited, non-recombining) and mitochondrial DNA (maternally inherited) provide independent genealogical records of male and female lineage histories, respectively. When these two markers te

y-chromosome mitochondrial-dna sex-biased-migration patrilocality matrilocality haplogroup
L_2_02 Genetics & Origins

L_2_02 — Population Genetics and Hardy-Weinberg Equilibrium

Population genetics — the mathematical study of allele frequency change in populations — provides the quantitative framework underlying evolutionary biology. The Hardy-Weinberg principle (1908), independently derived by

population genetics Hardy-Weinberg equilibrium allele frequency genetic drift natural selection migration
L_2_12 Verified Genetics & Origins

L_2_12 — Paleogenomics of Africa: The Cradle Revisited

Africa is the cradle of human evolution — the continent where Homo sapiens originated, where the deepest branches of the human family tree diverge, and where the greatest genetic diversity in our species is found. Yet pa

Africa paleogenomics ancient DNA African population structure deep divergence Khoe-San
L_2_15 Verified Genetics & Origins

L_2_15 — Population Structure of the Ancient Near East: Farming Spread Genetics

The Neolithic Revolution — the independent invention of agriculture in the Fertile Crescent (~10,000-8,000 BCE) — was one of the most consequential transformations in human history, and ancient DNA has revealed that the

Neolithic farming Near East Fertile Crescent Anatolia Levant
L_2_18 Verified Genetics & Origins

L_2_18 — Archaic Admixture in Africa (Ghost Populations)

While Neanderthal and Denisovan admixture in non-African populations has been well-documented since Svante Pääbo's landmark 2010 Neanderthal genome paper, evidence for archaic admixture within Africa represents a more re

archaic admixture ghost population African genetics ancient DNA introgression archaic hominin
L_3_16 Verified Genetics & Origins

L_3_16 — Genomic Imprinting & Evolutionary Conflict

Genomic imprinting — the epigenetic phenomenon in which a subset of genes (~100–200 in mammals) are expressed from only one parental allele, with the other allele silenced by DNA methylation and histone modification esta

genomic imprinting parent-of-origin expression epigenetics kinship theory parental conflict IGF2
L_3_17 Verified Genetics & Origins

L_3_17 — Endogenous Retroviruses (HERVs) in the Human Genome

Human endogenous retroviruses (HERVs) — remnants of ancient retroviral infections that integrated into the germline DNA of human ancestors and have been vertically transmitted through the host genome for millions of year

endogenous retroviruses HERVs HERV-K HERV-W syncytin retroviral integration
L_3_10 Verified Genetics & Origins

L_3_10 — Telomeres Aging and Longevity Genetics

Telomeres — the repetitive DNA sequences (TTAGGG in vertebrates) capping the ends of linear chromosomes — protect genome integrity by preventing chromosome ends from being recognized as double-strand breaks and triggerin

telomere telomerase aging senescence Hayflick limit shelterin
L_5_05 Verified Genetics & Origins

L_5_05 — Epigenetic Clocks: Measuring Biological Age

Epigenetic clocks are mathematical models that estimate biological age — the physiological age of an organism's cells and tissues — based on DNA methylation patterns at specific CpG sites (regions where a cytosine nucleo

epigenetic clock DNA methylation biological age Horvath clock Hannum clock GrimAge
Y_4_19 Credible Altered States

Y_4_19 — Ritual-Induced Ecstasy

Ritual-induced ecstasy — altered states of consciousness produced through collective ceremonial practices including dance, chanting, drumming, fasting, pain ordeal, and rhythmic movement — is one of the oldest and most u

ritual ecstasy trance collective effervescence Durkheim sacred dance
Y_4_03 Altered States

Y_4_03 — Shamanic Practices / Altered States Synthesis

Shamanic practices represent humanity's oldest spiritual technology, attested across every inhabited continent from at least 30,000 BCE (Upper Paleolithic cave art) to the present day. Despite vast cultural distances — g

shamanism altered states Mircea Eliade ecstasy trance soul journey
Y_5_07 Verified Altered States

Y_5_07 — Phenomenology of Pain and Pain Modulation

Pain — defined by the International Association for the Study of Pain (IASP, revised 2020) as "an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissu

pain nociception pain modulation gate control theory Melzack Wall
Y_5_01 Altered States

Y_5_01 — Remote Viewing & Psychic Programs

The U.S. government spent $20M+ over 23 years (1972–1995) investigating psychic phenomena under classified programs known collectively as "Stargate." Research was published in Nature (1974) and IEEE (1976). The program p

remote viewing Stargate SRI CIA DIA Targ
Y_2_01 Altered States

Y_2_01 — NDEs, OBEs & Consciousness Studies

Modern consciousness research — NDEs in cardiac arrest patients, children's past-life memories, and DMT-induced entity encounters — produces data that intersects remarkably with ancient descriptions of death journeys, as

NDE OBE near-death experience out-of-body AWARE study Parnia
Y_3_02 Altered States

Y_3_02 — Meditation, Neuroplasticity, and Contemplative Neuroscience

Meditation — the systematic training of attention and awareness — has been practiced for at least 3,000-5,000 years (earliest evidence: Indus Valley seal of a seated figure in meditation posture, ~2600 BCE; earliest text

meditation neuroplasticity mindfulness MBSR default mode network DMN
Y_3_09 Altered States

Y_3_09 — Prayer, Contemplation, and the Neuroscience of Religious Experience

The neuroscientific study of prayer and religious experience — sometimes termed neurotheology (d'Aquili & Newberg, 1999) — has moved from philosophical speculation to empirical investigation using neuroimaging, EEG, and

neurotheology prayer neuroscience Andrew Newberg SPECT prayer religious experience mystical experience
Y_3_07 Altered States

Y_3_07 — Music, Consciousness, and Altered States

Music is one of the most powerful modulators of conscious experience available without pharmacological intervention. Neuroimaging reveals that music engages an extraordinarily distributed network: auditory cortex (superi

music cognition music neuroscience chills frisson musical emotion default mode network music auditory cortex
H_2_09 Verified Suppression & Thesis

H_2_09 — The Galileo Affair — Science, Religion, and Power

The Galileo affair — the Roman Inquisition's condemnation of Galileo Galilei (1564–1642) for defending the Copernican heliocentric model — is the archetypal case of religious authority suppressing scientific knowledge, i

galileo galileo affair inquisition heliocentrism copernicus dialogue