RESEARCH BASE

Search 3,721 documents across 34 fields — every claim tier-rated by evidence

3,721 Documents 34 Sections 43,625 Citations 34,852 Keywords Indexed 4 Evidence Tiers

3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.

2,445 results for "Di Paolo" — page 14 of 123

ZD_5_02 Credible Information & Computation

ZD_5_02 — Digital Preservation and the Longevity of Knowledge

Digital preservation — the set of policies, strategies, and actions required to ensure continued access to digital information over time — addresses one of the great paradoxes of the information age: humanity is producin

digital preservation data longevity format obsolescence bit rot digital dark age archiving
ZD_4_17 Credible Information & Computation

ZD_4_17 — Digital Twin Technology

A digital twin is a virtual representation of a physical object, process, or system that is continuously updated with real-time data from its physical counterpart through sensors and IoT connectivity, enabling simulation

digital twin virtual replica simulation IoT predictive maintenance Grieves
L_1_13 Verified Genetics & Origins

L_1_13 — Homo Naledi: Underground Burial and Primitive Morphology

Homo naledi is one of the most unexpected and controversial hominin discoveries of the 21st century. Announced in 2015 by Lee Berger (University of the Witwatersrand) and an international team, the species was recovered

Homo naledi Rising Star Dinaledi Chamber Lee Berger primitive morphology hominin
L_2_16 Verified Genetics & Origins

L_2_16 — Genetic Diversity and Inbreeding: Population Health Across History

Genetic diversity — the total amount of genetic variation within a population — is a fundamental determinant of population health, adaptive potential, and long-term survival. The loss of diversity through inbreeding (mat

genetic diversity inbreeding consanguinity runs of homozygosity ROH inbreeding depression
L_3_11 Verified Genetics & Origins

L_3_11 — Genetics of Taste and Dietary Adaptation

Taste perception — the ability to detect sweet, salty, sour, bitter, and umami (savory) stimuli — is mediated by genetically encoded receptor proteins whose variation across individuals and populations reflects evolution

taste genetics TAS2R_4_05 PTC PROP bitter taste umami
L_5_03 Verified Genetics & Origins

L_5_03 — Pharmacogenomics and Ancestral Medicine

Pharmacogenomics — the study of how genetic variation influences individual responses to drugs — bridges genetics, pharmacology, and clinical medicine. Humans carry extensive polymorphism in genes encoding drug-metaboliz

pharmacogenomics CYP2D6 CYP2C_5_04 drug metabolism personalized medicine warfarin
L_5_06 Verified Genetics & Origins

L_5_06 — Genetic Adaptation to Disease: Malaria, Plague, TB

Infectious disease has been the most powerful selective force on the human genome throughout history. Pathogens — particularly malaria, plague, tuberculosis, smallpox, and cholera — have killed more humans than all other

natural selection disease adaptation malaria sickle cell G6PD Duffy antigen
L_5_08 Verified Genetics & Origins

L_5_08 — Ancient DNA from Sediments: Cave Dirt Genomics

One of the most revolutionary methodological advances in ancient DNA (aDNA) research has been the recovery of hominin DNA directly from cave sediments — without any bones or teeth. This technique, pioneered by Matthias M

sediment DNA environmental DNA eDNA cave sediment ancient DNA metagenomic
Y_4_17 Verified Altered States

Y_4_17 — Sleep Disorders & Parasomnias

Sleep disorders affect an estimated 50–70 million Americans and up to 45% of the global population, encompassing over 80 distinct conditions classified by the International Classification of Sleep Disorders (ICSD-3, 2014

sleep disorders parasomnias narcolepsy sleepwalking REM behavior disorder sleep terrors
Y_4_18 Verified Altered States

Y_4_18 — Sleep Disorders and Parasomnias: Pathologies of Consciousness in Sleep

Sleep disorders affect an estimated 50–70 million Americans and ~1 billion people globally, causing significant morbidity, mortality, and economic burden. The field was transformed by the discovery of distinct sleep stag

sleep-disorders parasomnia insomnia narcolepsy sleep-apnea rem-behavior-disorder
Y_2_01 Verified Altered States

Y_2_01 — NDEs, OBEs & Consciousness Studies

Modern consciousness research — NDEs in cardiac arrest patients, children's past-life memories, and DMT-induced entity encounters — produces data that intersects remarkably with ancient descriptions of death journeys, as

NDE OBE near-death experience out-of-body AWARE study Parnia
Y_2_15 Credible Altered States

Y_2_15 — Breathwork Traditions: Holotropic, Tummo, and Physiological Extremes

Breathwork — the deliberate manipulation of breathing patterns to induce altered physiological and psychological states — represents one of humanity's oldest and most accessible methods for modifying consciousness, with

breathwork holotropic-breathing tummo wim-hof-method pranayama hyperventilation
Y_3_01 Verified Altered States

Y_3_01 — Kundalini and Serpent Energy Traditions

Kundalini ("coiled one" in Sanskrit) describes a dormant serpent-like energy said to reside at the base of the spine, which, when "awakened" through meditation, breathwork, or spontaneous experience, rises through a cent

kundalini serpent energy chakras nadis subtle body yoga
Y_3_16 Verified Altered States

Y_3_16 — Vipassana: Insight Meditation Tradition

Vipassana (Pali: vipassanā, "clear seeing" or "insight") is one of the two primary modes of Buddhist meditation alongside samatha (calming/concentration), directed at cultivating direct experiential understanding of the

vipassana insight meditation satipatthana Theravada Mahasi Sayadaw S.N. Goenka
Y_1_17 Verified Altered States

Y_1_17 — Ketamine Therapy and Dissociative Medicine

Ketamine — a dissociative anesthetic synthesized by Calvin Stevens at Parke-Davis in 1962 and first used clinically by Edward Domino and Guenter Corssen in 1966 — has emerged as a revolutionary treatment for treatment-re

ketamine esketamine spravato depression treatment-resistant nmda-receptor
Y_1_18 Verified Altered States

Y_1_18 — Addiction Neurochemistry: Reward Circuits, Tolerance & Therapeutic Frontiers

Addiction — now formally termed substance use disorder (SUD, DSM-5) — is a chronic, relapsing brain disorder characterized by compulsive drug seeking despite harmful consequences, affecting approximately 35 million peopl

addiction neurochemistry dopamine-reward mesolimbic-pathway opioid-crisis tolerance-dependence
Y_1_07 Credible Altered States

Y_1_07 — Ego Dissolution and Psychedelic Neuroscience

Ego dissolution — the temporary loss of the subjective sense of self, personal boundaries, and the distinction between self and world — is among the most profound and therapeutically significant effects of serotonergic p

ego dissolution psychedelic neuroscience default mode network psilocybin LSD DMT
Y_1_10 Credible Altered States

Y_1_10 — Ibogaine: African Plant Medicine and Addiction Interruption

Ibogaine is a naturally occurring psychoactive indole alkaloid derived from the root bark of the West African shrub Tabernanthe iboga, which has been used for centuries in the Bwiti spiritual tradition of Gabon, Cameroon

ibogaine iboga Tabernanthe iboga Bwiti addiction interruption opioid withdrawal
H_2_01 Verified Suppression & Thesis

H_2_01 — Key Findings and Reliability Assessment

This is the capstone analysis document for the entire research project. It provides the quantitative and qualitative answer to the core question: Is the evidence overwhelmingly positive regarding ancient serpent beings a

reliability findings thesis evidence tier consensus
H_2_16 Credible Suppression & Thesis

H_2_16 — Dissident Scientists: Careers Destroyed by Heterodox Views

The history of science includes numerous cases of researchers whose careers were damaged, marginalized, or destroyed because they advanced ideas that contradicted the prevailing scientific paradigm — ideas that were, in

dissident heterodox heresy career suppression paradigm