RESEARCH BASE

Search 3,721 documents across 34 fields — every claim tier-rated by evidence

3,721 Documents 34 Sections 43,625 Citations 34,852 Keywords Indexed 4 Evidence Tiers

3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.

531 results for "DNA logic gates" — page 11 of 27

Z_3_05 Verified Molecular Biology

Z_3_05 — Viral Integration and Endogenous Retroviruses

Approximately 8% of the human genome consists of human endogenous retroviruses (HERVs) — the remnants of ancient retroviral infections that integrated into germline cells and were subsequently inherited vertically like a

endogenous retrovirus ERV HERV viral integration retrovirus reverse transcriptase
Z_2_15 Verified Molecular Biology

Z_2_15 — Future of Genomics and Personalized Medicine

Genomics is undergoing a transition from research tool to clinical infrastructure. The cost of whole-genome sequencing (WGS) has plummeted from $2.7 billion (Human Genome Project, 1990–2003) to ~$200 per genome (Illumina

future genomics personalized medicine precision medicine polygenic risk scores whole genome sequencing newborn screening
Z_2_10 Verified Molecular Biology

Z_2_10 — Genetics of Aging and Progeria

Aging — the progressive decline in physiological function leading to increased vulnerability to disease and death — has a substantial genetic component: twin studies estimate heritability of human lifespan at ~25–30% (He

aging genetics progeria Hutchinson-Gilford progeria HGPS LMNA lamin A
Z_2_09 Verified Molecular Biology

Z_2_09 — Mitochondrial Genetics and Diseases

Human mitochondrial DNA (mtDNA) is a 16,569-bp circular genome encoding 37 genes: 13 proteins (all subunits of the oxidative phosphorylation/OXPHOS complexes I, III, IV, and V), 22 transfer RNAs, and 2 ribosomal RNAs. Un

mitochondrial genetics mtDNA mitochondrial DNA mitochondrial disease oxidative phosphorylation OXPHOS
Z_2_23 Verified Molecular Biology

Z_2_23 — Immune System & Immunology

The immune system is a multi-layered defense network that protects organisms against pathogens including bacteria, viruses, fungi, and parasites. It comprises two interconnected arms: innate immunity, which provides rapi

immune system innate immunity adaptive immunity T cells B cells antibodies
Z_1_08 Verified Molecular Biology

Z_1_08 — Transposons and Mobile Genetic Elements

Transposable elements (TEs, transposons) — segments of DNA that can move or copy themselves to new genomic locations — are among the most abundant and influential components of eukaryotic genomes. Discovered by Barbara M

transposon mobile genetic element transposable element jumping gene Barbara McClintock retrotransposon
Z_1_04 Verified Molecular Biology

Z_1_04 — Gene Expression and Regulation

Gene expression regulation — the molecular mechanisms controlling when, where, and how much each gene is active — is the central process that enables a single genome to produce ~200 distinct cell types, orchestrate embry

gene expression regulation transcription factors promoter enhancer epigenetics
Z_1_05 Verified Molecular Biology

Z_1_05 — Genomic Imprinting and Parent-of-Origin Effects

Genomic imprinting is an epigenetic phenomenon in which a gene's expression depends on whether it was inherited from the mother or the father — violating the standard Mendelian assumption that both parental copies functi

genomic imprinting parent-of-origin effect epigenetics DNA methylation imprinting control region ICR
Z_1_03 Verified Molecular Biology

Z_1_03 — Human Genome Project and Its Legacy

The Human Genome Project (HGP), launched in 1990 and completed in 2003, was the largest coordinated biological research effort in history — a $3 billion, 13-year international collaboration to sequence all ~3.2 billion b

Human Genome Project HGP genome sequencing Francis Collins Craig Venter Celera
Z_1_12 Verified Molecular Biology

Z_1_12 — Genome Architecture and 3D Organization

The human genome — approximately 6.4 billion base pairs of DNA — is packed into a nucleus only ~6 μm in diameter. If stretched end-to-end, the DNA of a single human cell would extend about 2 meters, yet it is packaged an

genome architecture 3D genome chromatin organization topologically associating domains TADs chromosome territories
K_3_09 Credible Consciousness

K_3_09 — Minimal Consciousness and the Threshold of Sentience

Where does consciousness begin? This question — the problem of the threshold of sentience — is one of the most challenging in consciousness studies because it requires identifying what KIND of physical system is minimall

minimal consciousness sentience threshold consciousness markers biological consciousness single cell behavior bacterial cognition
K_3_02 Credible Consciousness

K_3_02 — Embodied Cognition

Embodied cognition is a broad research program challenging the classical cognitive science view that the mind is essentially a computer processing abstract symbols in the brain. Instead, embodied cognition holds that thi

embodied cognition 4E cognition embedded enacted extended embodied
K_3_05 Credible Consciousness

K_3_05 — Extended Mind and Cognitive Extension

The extended mind thesis (EMT), proposed by Andy Clark and David Chalmers in their landmark 1998 paper "The Extended Mind," argues that cognitive processes need not be confined within the skull — external objects, tools,

extended mind cognitive extension Clark and Chalmers parity principle Otto's notebook scaffolded cognition
K_4_01 Verified Consciousness

K_4_01 — Shamanism, Entheogens & Serpent Visions

Shamanism as a cross-cultural altered-state practice is Tier 1 anthropology (Eliade 1964, Winkelman 2010). Clinical psilocybin and DMT research is Tier 1 (Griffiths 2006/2019, Strassman 2001, Davis 2021). The consistent

shamanism DMT ayahuasca psilocybin Strassman Harner
K_4_14 Credible Consciousness

K_4_14 — Consciousness and Quantum Biology: Photosynthesis, Navigation, Smell

Quantum biology — the study of quantum mechanical effects playing functional roles in biological processes — has emerged as one of the most exciting interdisciplinary fields of the 21st century, with direct implications

quantum biology quantum coherence photosynthesis avian navigation olfaction radical pair
K_2_08 Credible Consciousness

K_2_08 — The Binding Problem in Consciousness

The binding problem asks how the brain creates unified, coherent conscious experiences from the distributed, specialized processing activity of millions of neurons across separate brain regions. When you see a red ball r

binding problem feature binding neural synchrony gamma oscillations temporal binding perceptual binding
K_5_04 Credible Consciousness

K_5_04 — Neuroscience of Belief

Belief — the mental state of holding something to be true — is a cornerstone of conscious experience, shaping perception, memory, emotion, decision-making, and behavior. The neuroscience of belief has revealed that belie

belief neuroscience belief formation cognitive biases confirmation bias belief perseverance motivated reasoning
K_5_18 Verified Consciousness

K_5_18 — Working Memory: Cognitive Architecture and Executive Function

Working memory (WM) is the cognitive system responsible for temporarily holding and manipulating information during complex tasks such as reasoning, language comprehension, and decision-making. Distinguished from passive

working memory short-term memory executive function baddeley phonological loop visuospatial sketchpad
K_5_16 Verified Consciousness

K_5_16 — Language, Inner Speech & Consciousness

The relationship between language and consciousness is one of the oldest problems in philosophy of mind and one of the most active frontiers of cognitive neuroscience. The central question — whether conscious thought req

inner speech language of thought Vygotsky Lev Vygotsky verbal thinking phonological loop
K_5_03 Credible Consciousness

K_5_03 — Psychosomatic Medicine and Mind–Body Interaction

Psychosomatic medicine investigates the bidirectional relationship between psychological processes and physical health — how mental states, emotions, beliefs, and social contexts influence bodily disease, and how physica

psychosomatic medicine mind-body interaction somatization functional somatic syndromes psychoneuroimmunology PNI