RESEARCH BASE
Search 3,721 documents across 34 fields — every claim tier-rated by evidence
3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.
38 results for "opioid receptor" — page 1 of 2
Y_1_12 — Salvia Divinorum: Mazatec Sage and Kappa-Opioid Visionary
Salvia divinorum ("diviner's sage") is a psychoactive plant of the mint family (Lamiaceae) native to the cloud forests of the Sierra Mazateca in Oaxaca, Mexico, where it has been used for centuries by Mazatec healers and
Z_2_12 — Genetics of Pain Perception
Pain perception — the subjective experience triggered by actual or potential tissue damage — varies enormously across individuals, with genetic factors accounting for 25–50% of the variance in pain sensitivity (twin stud
K_3_17 — Psychedelic Consciousness — DMT, Psilocybin Neural Effects
The psychedelic renaissance in neuroscience — a period of renewed scientific investigation beginning circa 2006 after decades of regulatory restriction — has produced an unprecedented body of neuroimaging, pharmacologica
X_2_13 — Pain Science: Nociception, Perception, and the Biopsychosocial Model
Pain is one of the most universal human experiences — and one of the most complex phenomena in medicine and neuroscience. The International Association for the Study of Pain (IASP) defines pain as "an unpleasant sensory
X_5_09 — Pharmacology: The Science of Drugs and Their Actions
Pharmacology — the science of drugs — investigates how chemical substances interact with biological systems to produce therapeutic, toxic, or other effects. The discipline encompasses pharmacokinetics (what the body does
X_4_15 — Addiction Medicine & Substance Abuse
Addiction medicine is a medical subspecialty formally recognised by the American Board of Medical Specialties (ABMS) in October 2015, though its intellectual roots stretch to Dr. Benjamin Rush's 1784 description of alcoh
X_3_09 — Anesthesia and Pain Management
Anesthesia and pain management — the medical control of pain and consciousness — revolutionized surgery and transformed the human experience of medical care. Before anesthesia, surgery was an ordeal of extreme suffering
X_3_29 — Pain Neuroscience: Gate Theory & Beyond
Pain neuroscience has undergone a revolution since the mid-twentieth century, transforming our understanding from a simple hardwired alarm system to a dynamic, modifiable experience shaped by neural circuits, cognition,
X_3_28 — Cancer Immunotherapy Revolution
Cancer immunotherapy — harnessing the body's own immune system to recognize and destroy tumor cells — has transformed oncology from a field dominated by surgery, radiation, and chemotherapy into one where the immune syst
Z_3_08 — Genetics of Taste and Smell
Taste and smell perception are profoundly shaped by genetics, with variation in chemosensory receptor genes producing dramatically different sensory worlds between individuals. The olfactory receptor (OR) gene family — d
Z_2_06 — Nutrigenomics and Diet-Gene Interactions
Nutrigenomics — the study of how genetic variation influences nutritional requirements, dietary responses, and disease susceptibility — and its complement nutrigenetics (how diet influences gene expression) represent a r
Z_2_11 — Genetics of Immunity and MHC Diversity
The major histocompatibility complex (MHC) — known as the human leukocyte antigen (HLA) system in humans — is the most polymorphic gene region in the human genome, encoding cell-surface glycoproteins essential for adapti
Z_2_23 — Immune System & Immunology
The immune system is a multi-layered defense network that protects organisms against pathogens including bacteria, viruses, fungi, and parasites. It comprises two interconnected arms: innate immunity, which provides rapi
Z_4_06 — Psychedelic Neurochemistry: 5-HT2A, Tryptamines, and Molecular Mechanisms
Psychedelic neurochemistry — the molecular-level study of how psychedelic compounds alter brain function to produce their characteristic effects (visual hallucinations, synesthesia, ego dissolution, mystical-type experie
Z_4_10 — Signal Transduction: How Cells Communicate
Signal transduction — the molecular mechanisms by which cells detect, interpret, and respond to external signals (hormones, growth factors, neurotransmitters, cytokines, environmental cues) — is one of the central organi
K_1_15 — Consciousness–Genetics Interface
Genetic variation significantly modulates conscious experience, including baseline personality, susceptibility to altered states, response to psychoactive substances, meditation capacity, and vulnerability to disorders o
K_5_02 — Pain, Consciousness, and the Nature of Suffering
Pain is one of the most philosophically revealing phenomena in consciousness studies: it is simultaneously a sensory detection system, an emotional experience, a cognitive evaluation, and a social communication — and the
INTERDOC_59 — Intergenerational Trauma: A Three-Channel Synthesis (Epigenetic, Psychological, Cultural)
Trauma is empirically heritable — but not through any single mechanism. The dominant public framing (epigenetics-as-Lamarckism) is overconfident; the dominant academic counter-framing (it's all attachment / it's all cult
INTERDOC_23 — Placebo, Nocebo, and the Biology of Belief
[KEY FINDING] The placebo effect is not "fake medicine" — it involves genuine, measurable physiological changes mediated by endogenous neurotransmitter systems. Fabrizio Benedetti (University of Turin) has demonstrated:
ZB_2_06 — Immune System Evolution: From Innate to Adaptive Defense
The immune system represents one of evolution's most complex adaptive innovations — a multi-layered defense system that distinguishes self from non-self and remembers past encounters. All multicellular organisms possess
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