RESEARCH BASE
Search 3,721 documents across 34 fields — every claim tier-rated by evidence
3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.
63 results for "drug resistance" — page 1 of 4
X_3_05 — Antibiotics and Antimicrobial Resistance
Antibiotics — substances that kill or inhibit bacterial growth — represent one of the most transformative medical discoveries in human history, having saved an estimated 200 million+ lives since their introduction. Their
X_3_25 — Antibiotic Resistance Crisis
Antimicrobial resistance (AMR) — the ability of microorganisms to survive exposure to drugs that once killed them — is one of the most serious threats to global public health in the twenty-first century. [KEY FINDING] A
X_5_09 — Pharmacology: The Science of Drugs and Their Actions
Pharmacology — the science of drugs — investigates how chemical substances interact with biological systems to produce therapeutic, toxic, or other effects. The discipline encompasses pharmacokinetics (what the body does
W_5_14 — Mapuche Civilization: Resistance, Cosmovision, and Araucanian Culture
The Mapuche ("People of the Land") — also historically known by the Spanish term Araucanians — are an indigenous people of south-central Chile and southwestern Argentina who achieved something nearly unique in the histor
ZF_4_05 — Marine Pharmacology and Drug Discovery
Marine pharmacology explores the ocean's vast biodiversity as a source of bioactive compounds for drug development — a field that has yielded several approved drugs and thousands of promising leads since the pioneering w
R_4_07 — Venom Evolution and Biochemical Arms Races
Venom — a cocktail of bioactive molecules injected via a specialized delivery apparatus (fangs, stingers, harpoons, nematocysts, spurs) to subdue prey, deter predators, or aid in competition — has evolved independently o
R_2_14 — Recent Human Evolution: Lactase Persistence, Altitude Adaptation, and Malaria Resistance
Human evolution did not stop with the emergence of Homo sapiens ~300,000 years ago — natural selection has continued to shape human biology in response to agriculture, diet, disease, climate, and altitude, producing some
S_2_11 — Bioinformatics: Computational Genomics and Drug Discovery
Bioinformatics — the application of computational methods to biological data — has become indispensable to modern biology and medicine, driven by the exponential growth of genomic, transcriptomic, proteomic, and metabolo
M_1_03 — Iron Pillar of Delhi — Unexplained Corrosion Resistance
The Iron Pillar of Delhi is a 7.21-meter, 6.5-tonne wrought iron column standing in the Qutb Minar complex in Mehrauli, New Delhi, dating to approximately 402 CE during the Gupta dynasty — most likely commissioned by Cha
X_5_19 — Drug Discovery: From Ethnobotany to Rational Design
Drug discovery is the process by which new therapeutic compounds are identified, developed, and brought to clinical use. The field has evolved through three major paradigms: (1) ethnobotanical/traditional knowledge — mos
X_5_20 — Medical Regulation: Clinical Trials, Drug Safety, and the History of Oversight
Medical regulation — the system of laws, agencies, and protocols governing drug development, clinical trials, and medical device approval — evolved over centuries from virtually no oversight to the elaborate global frame
Z_2_07 — Genetics of Disease Resistance
Infectious disease has been the most powerful selective force shaping the human genome, leaving signatures across thousands of loci. The best-understood example is sickle cell disease (HbS, Glu6Val in HBB): heterozygous
ZC_5_12 — Peasant Studies: Agrarian Change, Moral Economy, and Resistance
Peasant studies is an interdisciplinary field studying the economic, social, political, and cultural life of rural agricultural communities — peasantries — and the processes of agrarian change, resistance, and transforma
H_2_11 — Scientific Revolutions: Kuhn, Paradigm Shifts, and Resistance
Thomas Kuhn's The Structure of Scientific Revolutions (1962) fundamentally altered understanding of how science changes by arguing that scientific progress is not a smooth, cumulative accumulation of knowledge but rather
ZE_5_05 — Ethics of Civil Disobedience: Thoreau, Gandhi, King, and Nonviolent Resistance
Civil disobedience — the deliberate, public, nonviolent violation of law undertaken to protest injustice and appeal to the moral conscience of the community — occupies a distinctive position in political ethics. It is no
ZE_4_11 — Philosophy of Resistance: Civil Disobedience and Dissent
The philosophy of resistance — the ethical, political, and practical dimensions of civil disobedience, conscientious objection, nonviolent direct action, and revolutionary dissent — addresses one of the most fundamental
S_4_04 — Pandemic Risk — Ancient Plagues, Antibiotic Resistance, and Biosecurity
Pandemics have repeatedly reshaped human civilization, from the Plague of Justinian (541 CE, ~25-50 million dead, Yersinia pestis confirmed via ancient DNA) to the Black Death (1347-1353, killing 30-60% of Europe's popul
Z_3_13 — Horizontal Gene Transfer in Prokaryotes
Horizontal gene transfer (HGT) — the movement of genetic material between organisms outside of parent-to-offspring inheritance — is a dominant force shaping prokaryotic evolution, fundamentally challenging the traditiona
ZB_2_21 — Horizontal Gene Transfer & Microbial Evolution
Horizontal gene transfer (HGT) — also called lateral gene transfer (LGT) — is the transmission of genetic material between organisms by mechanisms other than parent-to-offspring (vertical) inheritance. HGT is the dominan
Y_1_16 — Psychedelic Legal Frameworks: Regulation, Decriminalization, and Therapeutic Access
The legal status of psychedelic substances — including psilocybin, LSD, MDMA, DMT/ayahuasca, mescaline, and ibogaine — has undergone dramatic shifts since the mid-20th century, moving from unregulated research compounds
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