RESEARCH BASE
Search 3,721 documents across 34 fields — every claim tier-rated by evidence
3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.
22 results for "tumor sequencing" — page 1 of 2
X_4_01 — Personalized and Genomic Medicine
Personalized medicine (also called precision medicine) represents the shift from one-size-fits-all treatment to therapies tailored to an individual's genetic profile, biomarkers, and molecular disease characteristics. Th
Z_2_16 — Cancer Genomics & Precision Oncology
Cancer genomics — the comprehensive analysis of the genetic alterations that drive cancer initiation, progression, and resistance to therapy — has transformed oncology from a tissue-of-origin classification system into a
S_2_12 — Personalized Medicine: Pharmacogenomics and Precision Health
Personalized medicine (also called precision medicine) tailors medical treatment to the individual characteristics of each patient — particularly their genetic makeup, but also incorporating biomarkers, environmental fac
L_4_13 — Ancient DNA: Methods, Revelations, and Ethical Debates
Ancient DNA (aDNA) — genetic material recovered from biological remains thousands to hundreds of thousands of years old — has revolutionized our understanding of human evolution, migration, and population history. The fi
X_3_08 — Cancer Research History
Cancer — the uncontrolled proliferation of abnormal cells — has been recognized since antiquity and remains the second leading cause of death globally (~10 million deaths in 2022, WHO). The history of cancer research is
X_3_18 — Immunotherapy: From Coley's Toxins to Checkpoint Inhibitors
Immunotherapy — harnessing the immune system to fight cancer and other diseases — was pioneered by William Coley (Memorial Hospital, New York), who injected bacterial toxins into inoperable sarcomas beginning in 1891 and
Z_5_06 — Circulating Cell-Free DNA: Liquid Biopsies and Non-Invasive Diagnostics
Circulating cell-free DNA (cfDNA) — fragments of DNA released into the bloodstream and other body fluids through cell death (apoptosis, necrosis), active secretion, and other mechanisms — has emerged as a revolutionary t
Z_5_02 — Metagenomics and Environmental DNA
Metagenomics — the sequencing and analysis of genetic material recovered directly from environmental samples without culturing organisms — has revealed that the vast majority of Earth's microbial diversity was invisible
Z_5_09 — Single-Cell Genomics: Profiling Biology One Cell at a Time
Single-cell genomics — the set of technologies that enable the measurement of DNA sequences, RNA expression, protein levels, or epigenetic states in individual cells rather than bulk populations — has revolutionized biol
Z_5_07 — Epigenome Mapping: Charting the Chemical Modifications of DNA and Chromatin
Epigenome mapping — the systematic, genome-wide identification and quantification of epigenetic modifications (chemical marks on DNA and histone proteins that regulate gene expression without changing the underlying DNA
Z_3_04 — Comparative Genomics and Cross-Species Analysis
Comparative genomics — the systematic comparison of genome sequences across species — has become the primary tool for understanding genome evolution, identifying functionally important sequences, and reconstructing the T
Z_2_15 — Future of Genomics and Personalized Medicine
Genomics is undergoing a transition from research tool to clinical infrastructure. The cost of whole-genome sequencing (WGS) has plummeted from $2.7 billion (Human Genome Project, 1990–2003) to ~$200 per genome (Illumina
Z_1_03 — Human Genome Project and Its Legacy
The Human Genome Project (HGP), launched in 1990 and completed in 2003, was the largest coordinated biological research effort in history — a $3 billion, 13-year international collaboration to sequence all ~3.2 billion b
Z_1_09 — Copy Number Variation and Structural Genomics
Copy number variations (CNVs) — segments of DNA ranging from ~1 kilobase to several megabases that are present in variable numbers across individuals — represent the most impactful form of genetic variation in the human
ZG_3_02 — FOXP2 and the Genetics of Language
FOXP2 (Forkhead Box Protein P2) is the first gene directly linked to human speech and language ability, located on chromosome 7q31 and encoding a transcription factor that regulates hundreds of downstream genes involved
G_4_17 — Microbiome Archaeology — Ancient Gut and Soil Microbes
Microbiome archaeology — the extraction and analysis of ancient microbial communities from archaeological materials (dental calculus, coprolites, mummified remains, soil sediments, ceramics) — has emerged since ~2012 as
G_1_05 — eDNA and Environmental DNA — Reading Invisible Life
Environmental DNA (eDNA) refers to genetic material shed by organisms into their environment — through skin cells, mucus, feces, urine, gametes, decomposing tissue, pollen, root exudates, and other biological residues —
ZD_4_08 — Bioinformatics and Computational Biology
Bioinformatics — the application of computational methods to biological data, especially molecular sequences — has become indispensable to modern biology. The field emerged from the convergence of molecular biology's dat
L_4_05 — Paleogenomics Methods and Ancient DNA
Paleogenomics — the study of ancient genomes — has transformed archaeology, anthropology, and evolutionary biology over the past two decades, recognized by the 2022 Nobel Prize in Physiology or Medicine awarded to Svante
L_4_01 — Ancient DNA from Sediment — Environmental DNA Revolution
Environmental DNA (eDNA) recovery from sediments has revolutionized our ability to detect the presence of organisms — including ancient humans — without requiring the discovery of any bones, teeth, or artifacts. The land
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