RESEARCH BASE

Search 3,721 documents across 34 fields — every claim tier-rated by evidence

3,721 Documents 34 Sections 43,625 Citations 34,852 Keywords Indexed 4 Evidence Tiers

3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.

9 results for "substance"

P_5_11 Verified Philosophy & Meaning

P_5_11 — Spinoza: Substance Monism, Ethics as Geometry, Conatus

Baruch (Benedict) de Spinoza (1632-1677), a Dutch philosopher of Portuguese-Jewish origin, constructed one of the most radical and rigorous metaphysical systems in the history of philosophy — presented in his masterwork,

Spinoza Baruch Spinoza Benedict Spinoza substance monism Ethics Deus sive Natura
X_4_15 Verified Medicine & Healing

X_4_15 — Addiction Medicine & Substance Abuse

Addiction medicine is a medical subspecialty formally recognised by the American Board of Medical Specialties (ABMS) in October 2015, though its intellectual roots stretch to Dr. Benjamin Rush's 1784 description of alcoh

addiction medicine substance use disorder opioid epidemic harm reduction mesolimbic pathway dopamine
Y_1_16 Verified Altered States

Y_1_16 — Psychedelic Legal Frameworks: Regulation, Decriminalization, and Therapeutic Access

The legal status of psychedelic substances — including psilocybin, LSD, MDMA, DMT/ayahuasca, mescaline, and ibogaine — has undergone dramatic shifts since the mid-20th century, moving from unregulated research compounds

psychedelic law psilocybin MDMA Schedule I decriminalization right to try
K_1_11 Verified Consciousness

K_1_11 — Dualism: Mind-Body Problem Across Philosophy and Neuroscience

The mind-body problem — the question of how subjective mental experience (consciousness, thought, sensation, emotion) relates to the physical body (brain, nervous system, matter) — is arguably the oldest and most persist

dualism mind-body problem substance dualism property dualism Descartes Chalmers
T_2_07 Verified Psychology & Social

T_2_07 — Psychology of Addiction

Addiction — compulsive engagement with a substance or behavior despite harmful consequences — is now understood as a chronic brain disorder involving neuroplastic changes in reward, motivation, memory, and executive cont

addiction psychology substance use disorder dopamine reward incentive sensitization tolerance dependence
Y_1_18 Verified Altered States

Y_1_18 — Addiction Neurochemistry: Reward Circuits, Tolerance & Therapeutic Frontiers

Addiction — now formally termed substance use disorder (SUD, DSM-5) — is a chronic, relapsing brain disorder characterized by compulsive drug seeking despite harmful consequences, affecting approximately 35 million peopl

addiction neurochemistry dopamine-reward mesolimbic-pathway opioid-crisis tolerance-dependence
H_4_06 Verified Suppression & Thesis

H_4_06 — Suppression of Psychedelic Research (1960s–2000s)

From the late 1940s through the mid-1960s, psychedelic substances — particularly LSD (lysergic acid diethylamide) and psilocybin — were the subject of extensive legitimate scientific research, with over 1,000 peer-review

psychedelics Schedule I LSD psilocybin MDMA Controlled Substances Act
P_3_07 Verified Philosophy & Meaning

P_3_07 — Aristotle — Natural Philosophy, Cosmology, and Legacy

Aristotle (384–322 BCE) was a Greek philosopher and polymath whose works constitute the single most influential body of thought in the history of Western and Islamic intellectual tradition. A student of Plato for twenty

Aristotle Lyceum natural philosophy four causes unmoved mover Prime Mover
R_1_14 Verified Biology & Evolution

R_1_14 — Biofilms: Microbial Communities, Quorum Sensing, and Cooperation

Biofilms are structured communities of microorganisms — bacteria, archaea, fungi, and algae — attached to surfaces and embedded in a self-produced matrix of extracellular polymeric substances (EPS): polysaccharides, prot

biofilm quorum sensing extracellular polymeric substance EPS microbial community antibiotic resistance