RESEARCH BASE

Search 3,721 documents across 34 fields — every claim tier-rated by evidence

3,721 Documents 34 Sections 43,625 Citations 34,852 Keywords Indexed 4 Evidence Tiers

3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.

5 results for "site-directed mutagenesis"

Z_5_10 Verified Molecular Biology

Z_5_10 — Genome Editing Beyond CRISPR: TALENs, Base Editors, Prime Editors, and Next-Generation Tools

While CRISPR-Cas9 (covered in Z_1_02) dominates the genome editing landscape, it is neither the first nor the only precision genome editing technology. The field began with zinc finger nucleases (ZFNs) in the early 2000s

genome editing TALENs zinc finger nucleases ZFN base editing prime editing

Z_2_05 Verified Molecular Biology

Z_2_05 — Gene Therapy: History and Progress

Gene therapy — the introduction, alteration, or replacement of genetic material within a patient's cells to treat or cure disease — has evolved from a speculative concept to an approved clinical reality over five decades

gene therapy gene replacement viral vector adeno-associated virus AAV lentivirus

Z_1_08 Verified Molecular Biology

Z_1_08 — Transposons and Mobile Genetic Elements

Transposable elements (TEs, transposons) — segments of DNA that can move or copy themselves to new genomic locations — are among the most abundant and influential components of eukaryotic genomes. Discovered by Barbara M

transposon mobile genetic element transposable element jumping gene Barbara McClintock retrotransposon

Z_1_16 Verified Molecular Biology

Z_1_16 — Transposable Elements: Jumping Genes and Genome Evolution

Transposable elements (TEs) — sequences of DNA capable of moving ("jumping") from one genomic location to another — constitute approximately 45% of the human genome and up to 85% of the maize genome, making them the sing

transposable elements jumping genes Barbara McClintock retrotransposons DNA transposons Alu elements

E_1_08 Verified Cataclysms & Chronology

E_1_08 — Ancient Supernovae and Their Cultural Impact

Supernovae — the explosive deaths of massive stars — are among the most energetic events in the universe, capable of briefly outshining entire galaxies. When they occur within our galaxy at distances of a few thousand li

supernova SN 1054 Crab Nebula Anasazi petroglyph SN 185 Vela supernova

BROWSE BY SECTION — 3,721 documents across 34 fields

A Foundations 112 Docs B Beings & Entities 114 Docs C Global Traditions 116 Docs D Sites & Artifacts 116 Docs E Cataclysms & Chronology 109 Docs F Lost Connections 111 Docs G Modern Frameworks 99 Docs H Suppression & Thesis 95 Docs I UAP Disclosure 87 Docs J Ancient Technology 103 Docs K Consciousness 105 Docs L Genetics & Origins 92 Docs M Forbidden Archaeology 103 Docs N Secret Societies 87 Docs O Earth Anomalies 108 Docs P Philosophy & Meaning 104 Docs Q Cosmology & Physics 100 Docs R Biology & Evolution 95 Docs S Future Technology 100 Docs T Psychology & Social 112 Docs U Art, Music & Culture 122 Docs V Mathematics & Information 87 Docs W World Civilizations 140 Docs X Medicine & Healing 126 Docs Y Altered States 108 Docs Z Molecular Biology 112 Docs ZA Physics & Quantum 117 Docs ZB Ecology & Biology 117 Docs ZC Social Science 111 Docs ZD Information & Computation 96 Docs ZE Ethics & Applied Philosophy 99 Docs ZF Oceanography 105 Docs ZG Linguistics & Communication 110 Docs ZH Archaeoastronomy 114 Docs