RESEARCH BASE
Search 3,717 documents across 34 fields — every claim tier-rated by evidence
18 results for "serotonin"
K_3_17 — Psychedelic Consciousness — DMT, Psilocybin Neural Effects
The psychedelic renaissance in neuroscience — a period of renewed scientific investigation beginning circa 2006 after decades of regulatory restriction — has produced an unprecedented body of neuroimaging, pharmacologica
Y_5_20 — MDMA Pharmacology: Entactogen Mechanisms, Therapeutic Potential, and Risks
MDMA (3,4-methylenedioxymethamphetamine), commonly known as ecstasy or molly, is a synthetic entactogen (from Latin tactus, "touching within") that produces profound feelings of emotional closeness, empathy, trust, and w
Z_5_18 — Gut-Brain Axis: The Microbiome-Nervous System Connection
The gut-brain axis — the bidirectional communication network between the gastrointestinal tract and the central nervous system — has emerged as one of the most transformative concepts in modern biology and medicine. The
Z_3_14 — Behavioral Genetics and the Genetics of Aggression
Behavioral genetics investigates the relative contributions of genetic and environmental factors to variation in behavior — including aggression, impulsivity, risk-taking, anxiety, sociability, and cognitive traits. Twin
Z_4_06 — Psychedelic Neurochemistry: 5-HT2A, Tryptamines, and Molecular Mechanisms
Psychedelic neurochemistry — the molecular-level study of how psychedelic compounds alter brain function to produce their characteristic effects (visual hallucinations, synesthesia, ego dissolution, mystical-type experie
Z_4_01 — Human Microbiome, Gut-Brain Axis, and the Holobiont Concept
The human microbiome — the ~38 trillion microbial cells (bacteria, archaea, fungi, viruses) inhabiting the human body — constitutes a co-evolved ecosystem that profoundly influences health, immunity, metabolism, developm
K_1_15 — Consciousness–Genetics Interface
Genetic variation significantly modulates conscious experience, including baseline personality, susceptibility to altered states, response to psychoactive substances, meditation capacity, and vulnerability to disorders o
INTERDOC_20 — Psychedelic Neuroscience and Ancient Ritual Practice
[KEY FINDING] The Johns Hopkins Center for Psychedelic and Consciousness Research, the Imperial College Centre for Psychedelic Research (est. 2019, directed by Robin Carhart-Harris), and the MAPS (Multidisciplinary Assoc
T_2_17 — Depression & Mood Disorders
Major Depressive Disorder (MDD) affects an estimated 280 million people worldwide (WHO, 2023) and is the leading cause of disability globally. The neurobiological understanding of depression has undergone a paradigm shif
T_2_16 — Body Dysmorphic Disorder
Body dysmorphic disorder (BDD) is a psychiatric condition characterized by persistent, distressing preoccupation with perceived defects or flaws in physical appearance that are not observable or appear slight to others.
T_1_19 — Depression: Neurobiology, Treatment Evolution & Cultural Perspectives
Major depressive disorder (MDD) — affecting approximately 280 million people worldwide (WHO, 2021) and ranking as the leading cause of disability globally — is a heterogeneous condition whose neurobiology remains incompl
L_3_07 — Behavioral Genetics: Nature and Nurture
Behavioral genetics — the scientific study of how genetic and environmental factors contribute to individual differences in behavior — has transformed our understanding of human psychology over the past half-century. Thr
L_5_12 — Microbiome-Consciousness Connection: Gut-Brain Axis and Microbial Influence on Mind
The microbiome-gut-brain axis — the bidirectional communication network linking the ~38 trillion microorganisms inhabiting the human gastrointestinal tract with the central nervous system — has emerged as one of the most
L_5_13 — The Microbiome-Brain Axis: Gut Bacteria, Mood & Consciousness
The microbiome-gut-brain axis — bidirectional communication between the trillions of gut microorganisms and the central nervous system — has emerged as one of the most significant frontiers in neuroscience and consciousn
Y_5_03 — Pineal Gland / Third Eye Across Cultures
The pineal gland sits at the geometric center of the brain and has been called "the third eye" across cultures for millennia. Ancient pine cone motifs appear at the Vatican (Cortile della Pigna), Assyrian reliefs (winged
Y_1_19 — Ibogaine Reset Mechanism
Ibogaine — a naturally occurring psychoactive indole alkaloid extracted from the root bark of Tabernanthe iboga, a shrub native to the equatorial forests of Gabon and Cameroon — has emerged as one of the most pharmacolog
Y_1_06 — Psychedelic Research — Modern Science and Ancient Entheogen Parallels
Psychedelic research has undergone a dramatic revival since ~2006, with major studies at Johns Hopkins, Imperial College London, NYU, and MAPS demonstrating the therapeutic potential of psilocybin, MDMA, and ayahuasca/DM
R_2_09 — Self-Domestication Hypothesis — Did Humans Tame Themselves?
The human self-domestication hypothesis proposes that Homo sapiens underwent a domestication process analogous to that of dogs, livestock, and Belyaev's experimentally domesticated foxes — but without an external domesti
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