RESEARCH BASE
Search 3,721 documents across 34 fields — every claim tier-rated by evidence
3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.
78 results for "psychedelic threshold" — page 1 of 4
INTERDOC_63 — Sensory Gating as Universal Consciousness Threshold Modulator
Melzack and Wall's gate control theory (1965, Science) demonstrated that pain perception is not direct signal transmission but filtered through a spinal "gate" modulated by large-fiber input, small-fiber input, and desce
X_2_03 — Psychedelic Medicine: Clinical Evidence and Renaissance
The psychedelic renaissance — the resurgence of clinical research into psychedelic compounds after decades of prohibition — represents one of the most significant paradigm shifts in modern psychiatry. Psilocybin for trea
K_3_17 — Psychedelic Consciousness — DMT, Psilocybin Neural Effects
The psychedelic renaissance in neuroscience — a period of renewed scientific investigation beginning circa 2006 after decades of regulatory restriction — has produced an unprecedented body of neuroimaging, pharmacologica
INTERDOC_20 — Psychedelic Neuroscience and Ancient Ritual Practice
[KEY FINDING] The Johns Hopkins Center for Psychedelic and Consciousness Research, the Imperial College Centre for Psychedelic Research (est. 2019, directed by Robin Carhart-Harris), and the MAPS (Multidisciplinary Assoc
Y_1_04 — Psychedelic Renaissance — Clinical Research and Consciousness
The psychedelic renaissance — a resurgence of rigorous scientific research on psychedelic substances after decades of prohibition — has produced some of the most significant findings in 21st-century psychiatry and consci
Y_1_06 — Psychedelic Research — Modern Science and Ancient Entheogen Parallels
Psychedelic research has undergone a dramatic revival since ~2006, with major studies at Johns Hopkins, Imperial College London, NYU, and MAPS demonstrating the therapeutic potential of psilocybin, MDMA, and ayahuasca/DM
Y_1_15 — Micro-Dosing: Sub-Perceptual Psychedelic Use and Cognitive Effects
Micro-dosing — the practice of regularly consuming sub-perceptual doses (typically 1/10th to 1/20th of a standard recreational dose) of psychedelic substances, most commonly LSD (~10–20 micrograms) or psilocybin (~0.1–0.
Y_1_07 — Ego Dissolution and Psychedelic Neuroscience
Ego dissolution — the temporary loss of the subjective sense of self, personal boundaries, and the distinction between self and world — is among the most profound and therapeutically significant effects of serotonergic p
Y_1_16 — Psychedelic Legal Frameworks: Regulation, Decriminalization, and Therapeutic Access
The legal status of psychedelic substances — including psilocybin, LSD, MDMA, DMT/ayahuasca, mescaline, and ibogaine — has undergone dramatic shifts since the mid-20th century, moving from unregulated research compounds
Y_1_01 — Altered States, Psychedelics & Ancient Knowledge
Psychoactive substances played a significant — possibly central — role in ancient knowledge traditions. The Eleusinian Mysteries (kykeon), Vedic tradition (Soma), Egyptian practice (blue lotus), and Mesoamerican religion
H_4_06 — Suppression of Psychedelic Research (1960s–2000s)
From the late 1940s through the mid-1960s, psychedelic substances — particularly LSD (lysergic acid diethylamide) and psilocybin — were the subject of extensive legitimate scientific research, with over 1,000 peer-review
ZE_3_06 — Ethics of Psychedelic Research and Therapy
The ethics of psychedelic research and therapy addresses the unique moral challenges posed by substances that profoundly alter consciousness in therapeutic, religious, and research contexts. After a 40-year research mora
X_5_26 — Psychedelic Medicine: The Johns Hopkins Center and the Therapeutic Renaissance
The psychedelic therapy renaissance — centered at the Johns Hopkins Center for Psychedelic and Consciousness Research (established 2019, originally launched as a research program in 2000) — represents one of the most sig
INTERDOC_72 — The Psychedelic Entropy Paradox: Coherence Through Anarchy
The "Entropic Brain" hypothesis, pioneered by Robin Carhart-Harris (Imperial College London), demonstrates that under the influence of classic psychedelics (psilocybin, LSD, DMT), the brain's Default Mode Network (DMN) d
C_5_23 — Threshold Guardian: The Universal Gatekeeper Archetype
The Threshold Guardian — a supernatural figure stationed at the boundary between profane and sacred space, between the known world and the unknown, between life and death — is one of the most universal archetypes in worl
Z_4_06 — Psychedelic Neurochemistry: 5-HT2A, Tryptamines, and Molecular Mechanisms
Psychedelic neurochemistry — the molecular-level study of how psychedelic compounds alter brain function to produce their characteristic effects (visual hallucinations, synesthesia, ego dissolution, mystical-type experie
K_3_09 — Minimal Consciousness and the Threshold of Sentience
Where does consciousness begin? This question — the problem of the threshold of sentience — is one of the most challenging in consciousness studies because it requires identifying what KIND of physical system is minimall
TH_02 — The Metabolic Consciousness Threshold
Here's a question that sounds purely philosophical but might actually have a number for an answer: how much energy does it take to be conscious? This theory says there's a floor — a minimum amount of power a system must
Y_4_16 — Hypnagogia: The Threshold State Between Waking and Sleep
Hypnagogia is the transitional state of consciousness experienced during the onset of sleep (waking-to-sleep), characterized by vivid spontaneous imagery, auditory hallucinations, distorted body perception, and loosened
Y_4_06 — Synesthesia and Cross-Modal Perception
Synesthesia — the involuntary, consistent experience of one sensory modality triggering perception in another (e.g., hearing colors, tasting shapes) — affects roughly 4% of the general population when broad subtype defin
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