RESEARCH BASE
Search 3,721 documents across 34 fields — every claim tier-rated by evidence
3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.
20 results for "pathogen"
L_4_14 — Ancient Pathogen Genomics
Ancient pathogen genomics — the recovery, sequencing, and analysis of pathogen DNA from archaeological remains — has revolutionized our understanding of past pandemics, pathogen evolution, and human-disease coevolution.
Z_3_03 — Ancient Pathogen Genomics — Plague, TB, Smallpox DNA
Ancient pathogen genomics — the recovery and sequencing of disease-causing organism DNA from archaeological remains — has revolutionized understanding of human disease history. Beginning with the landmark reconstruction
ZB_5_12 — Wildlife Disease Ecology: Pathogens in Wild Populations
Wildlife disease ecology examines how infectious diseases (caused by viruses, bacteria, fungi, protists, and metazoan parasites) operate within wild animal and plant populations, investigating transmission dynamics, host
L_4_16 — Ancient Pathogen Genomics: Disease DNA from the Archaeological Record
Ancient pathogen genomics — the recovery and analysis of microbial DNA from archaeological remains — has revolutionized understanding of historical pandemics and pathogen evolution. The field was transformed when Johanne
L_5_06 — Genetic Adaptation to Disease: Malaria, Plague, TB
Infectious disease has been the most powerful selective force on the human genome throughout history. Pathogens — particularly malaria, plague, tuberculosis, smallpox, and cholera — have killed more humans than all other
X_5_15 — Paleopathology: Disease in Antiquity
Paleopathology — the study of disease in ancient human and animal remains — provides direct evidence of health, nutrition, and disease in past populations, bridging archaeology and medicine. Marc Armand Ruffer (Cairo Sch
X_3_20 — Infectious Disease & Epidemiology
Infectious diseases have shaped human history more profoundly than any other biological force. The germ theory of disease, established by Louis Pasteur and Robert Koch in the 1860s–1880s, transformed medicine from specul
X_3_25 — Antibiotic Resistance Crisis
Antimicrobial resistance (AMR) — the ability of microorganisms to survive exposure to drugs that once killed them — is one of the most serious threats to global public health in the twenty-first century. [KEY FINDING] A
Z_3_13 — Horizontal Gene Transfer in Prokaryotes
Horizontal gene transfer (HGT) — the movement of genetic material between organisms outside of parent-to-offspring inheritance — is a dominant force shaping prokaryotic evolution, fundamentally challenging the traditiona
Z_2_11 — Genetics of Immunity and MHC Diversity
The major histocompatibility complex (MHC) — known as the human leukocyte antigen (HLA) system in humans — is the most polymorphic gene region in the human genome, encoding cell-surface glycoproteins essential for adapti
Z_2_07 — Genetics of Disease Resistance
Infectious disease has been the most powerful selective force shaping the human genome, leaving signatures across thousands of loci. The best-understood example is sickle cell disease (HbS, Glu6Val in HBB): heterozygous
Z_2_01 — HLA System & Archaic Immune Inheritance
The Human Leukocyte Antigen (HLA) system is the most polymorphic region of the human genome, encoding cell-surface proteins critical to adaptive immune function. Located on chromosome 6p21.3, the Major Histocompatibility
ZB_2_17 — Mycology: Kingdom Fungi
Kingdom Fungi — the second-largest kingdom of eukaryotes after animals, with an estimated 2.2–3.8 million species (only ~150,000 described) — encompasses organisms that obtain nutrition by absorbing dissolved organic mol
L_3_09 — HLA Diversity and Immune System Evolution
The Human Leukocyte Antigen (HLA) system — the human version of the Major Histocompatibility Complex (MHC) found in all jawed vertebrates — is the most polymorphic gene region in the entire human genome. Located on chrom
L_5_04 — Ancient Microbiome and Paleomicrobiology
Paleomicrobiology — the study of ancient microorganisms through the application of molecular techniques (ancient DNA extraction, metagenomics, proteomics) to archaeological and paleontological material — has revolutioniz
Y_5_20 — MDMA Pharmacology: Entactogen Mechanisms, Therapeutic Potential, and Risks
MDMA (3,4-methylenedioxymethamphetamine), commonly known as ecstasy or molly, is a synthetic entactogen (from Latin tactus, "touching within") that produces profound feelings of emotional closeness, empathy, trust, and w
R_5_06 — Fungal Kingdom: Deep Evolution, Networks, and Ecological Dominance
The Kingdom Fungi — comprising an estimated 2.2–3.8 million species (of which only ~150,000 have been formally described) — is one of the most ecologically dominant, evolutionarily ancient, and biologically consequential
S_4_04 — Pandemic Risk — Ancient Plagues, Antibiotic Resistance, and Biosecurity
Pandemics have repeatedly reshaped human civilization, from the Plague of Justinian (541 CE, ~25-50 million dead, Yersinia pestis confirmed via ancient DNA) to the Black Death (1347-1353, killing 30-60% of Europe's popul
F_3_10 — Plague and Disease Transmission Along Trade Routes
The same trade routes and migration corridors that connected distant civilizations also served as highways for pandemic disease, making pathogen transmission one of the most consequential — and devastating — forms of "lo
X_5_23 — Zoonotic Disease: Pathogen Spillover from Animals to Humans
Zoonotic diseases — infections that transmit from animals to humans — constitute approximately 60–75% of all emerging infectious diseases and have caused the most devastating pandemics in human history. The Neolithic rev
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