RESEARCH BASE

Search 3,721 documents across 34 fields — every claim tier-rated by evidence

3,721 Documents 34 Sections 43,625 Citations 34,852 Keywords Indexed 4 Evidence Tiers

3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.

6 results for "orphan diseases"

X_5_03 Verified Medicine & Healing

X_5_03 — Medical Genetics and Rare Diseases

Medical genetics is the branch of medicine concerned with the diagnosis, management, and counseling of individuals and families affected by genetic disorders — conditions caused by mutations in DNA, ranging from single-g

medical genetics rare diseases genetic disorders inborn errors Garrod orphan diseases

X_4_12 Verified Medicine & Healing

X_4_12 — Tropical Medicine: Disease, Ecology, and Global Health in the Tropics

Tropical medicine is the branch of medicine concerned with diseases that are prevalent or unique to tropical and subtropical regions — particularly vector-borne diseases (malaria, dengue, yellow fever, Chagas disease, le

tropical medicine neglected tropical diseases malaria dengue Chagas schistosomiasis

Z_2_08 Verified Molecular Biology

Z_2_08 — Prion Genetics and Misfolded Proteins

Prions are infectious agents composed entirely of misfolded protein — the only known pathogen that contains no nucleic acid (no DNA, no RNA). The protein-only hypothesis (Stanley Prusiner, 1982 — Nobel Prize 1997) states

prion PRNP PrP PrPSc PrPC prion diseases

Z_2_09 Verified Molecular Biology

Z_2_09 — Mitochondrial Genetics and Diseases

Human mitochondrial DNA (mtDNA) is a 16,569-bp circular genome encoding 37 genes: 13 proteins (all subunits of the oxidative phosphorylation/OXPHOS complexes I, III, IV, and V), 22 transfer RNAs, and 2 ribosomal RNAs. Un

mitochondrial genetics mtDNA mitochondrial DNA mitochondrial disease oxidative phosphorylation OXPHOS

Z_4_18 Verified Molecular Biology

Z_4_18 — Protein Misfolding and Prion Diseases

Prion diseases — transmissible spongiform encephalopathies (TSEs) — are fatal neurodegenerative disorders caused by the misfolding and self-propagating aggregation of a normal cellular protein (PrPᶜ) into a pathological

prion protein-misfolding amyloid bse cjd mad-cow-disease

L_5_02 Verified Genetics & Origins

L_5_02 — Genetic Diseases and Founder Effect Populations

When a small group founds a new population and subsequently expands in relative isolation, genetic drift can amplify alleles that were rare in the ancestral population — including deleterious recessive disease alleles. T

founder effect genetic disease Tay-Sachs sickle cell cystic fibrosis Ashkenazi

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