RESEARCH BASE
Search 3,721 documents across 34 fields — every claim tier-rated by evidence
3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.
24 results for "opioid epidemic" — page 1 of 2
X_4_15 — Addiction Medicine & Substance Abuse
Addiction medicine is a medical subspecialty formally recognised by the American Board of Medical Specialties (ABMS) in October 2015, though its intellectual roots stretch to Dr. Benjamin Rush's 1784 description of alcoh
B_1_26 — Plague Deities: Disease Gods and Epidemic Mythology
Plague deities — gods and spirits who send, embody, or control epidemic disease — appear across cultures as humanity's theological response to one of its oldest and most terrifying enemies: mass contagion. Unlike natural
Y_1_12 — Salvia Divinorum: Mazatec Sage and Kappa-Opioid Visionary
Salvia divinorum ("diviner's sage") is a psychoactive plant of the mint family (Lamiaceae) native to the cloud forests of the Sierra Mazateca in Oaxaca, Mexico, where it has been used for centuries by Mazatec healers and
X_3_03 — Epidemic and Pandemic History
Epidemics and pandemics — the outbreak and widespread transmission of infectious disease — have shaped human civilization as profoundly as wars, technologies, and ideas. Ancient: the Plague of Athens (430 BCE, described
X_2_13 — Pain Science: Nociception, Perception, and the Biopsychosocial Model
Pain is one of the most universal human experiences — and one of the most complex phenomena in medicine and neuroscience. The International Association for the Study of Pain (IASP) defines pain as "an unpleasant sensory
X_5_29 — Epidemiology and Pandemics: Disease, Civilization, and the Biology of Outbreaks
Epidemiology — the study of disease distribution and determinants in populations — has fundamentally shaped human history, often more decisively than warfare or politics. The Antonine Plague (165–180 CE, likely smallpox)
X_3_09 — Anesthesia and Pain Management
Anesthesia and pain management — the medical control of pain and consciousness — revolutionized surgery and transformed the human experience of medical care. Before anesthesia, surgery was an ordeal of extreme suffering
X_3_29 — Pain Neuroscience: Gate Theory & Beyond
Pain neuroscience has undergone a revolution since the mid-twentieth century, transforming our understanding from a simple hardwired alarm system to a dynamic, modifiable experience shaped by neural circuits, cognition,
Z_3_03 — Ancient Pathogen Genomics — Plague, TB, Smallpox DNA
Ancient pathogen genomics — the recovery and sequencing of disease-causing organism DNA from archaeological remains — has revolutionized understanding of human disease history. Beginning with the landmark reconstruction
Z_2_12 — Genetics of Pain Perception
Pain perception — the subjective experience triggered by actual or potential tissue damage — varies enormously across individuals, with genetic factors accounting for 25–50% of the variance in pain sensitivity (twin stud
K_5_02 — Pain, Consciousness, and the Nature of Suffering
Pain is one of the most philosophically revealing phenomena in consciousness studies: it is simultaneously a sensory detection system, an emotional experience, a cognitive evaluation, and a social communication — and the
INTERDOC_23 — Placebo, Nocebo, and the Biology of Belief
[KEY FINDING] The placebo effect is not "fake medicine" — it involves genuine, measurable physiological changes mediated by endogenous neurotransmitter systems. Fabrizio Benedetti (University of Turin) has demonstrated:
T_2_07 — Psychology of Addiction
Addiction — compulsive engagement with a substance or behavior despite harmful consequences — is now understood as a chronic brain disorder involving neuroplastic changes in reward, motivation, memory, and executive cont
ZD_4_13 — Network Science: Graph Theory, Small Worlds, and Scale-Free Networks
Network science is the study of complex systems represented as networks (graphs) — collections of nodes (vertices) connected by edges (links) — encompassing social networks (people connected by friendships, collaboration
Y_4_12 — Psychosomatic Phenomena and the Placebo Effect
Psychosomatic phenomena — bodily changes produced by mental states — and the placebo effect — measurable physiological improvements following inert treatment — demonstrate that consciousness and belief can directly affec
Y_5_07 — Phenomenology of Pain and Pain Modulation
Pain — defined by the International Association for the Study of Pain (IASP, revised 2020) as "an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissu
Y_1_19 — Ibogaine Reset Mechanism
Ibogaine — a naturally occurring psychoactive indole alkaloid extracted from the root bark of Tabernanthe iboga, a shrub native to the equatorial forests of Gabon and Cameroon — has emerged as one of the most pharmacolog
Y_1_18 — Addiction Neurochemistry: Reward Circuits, Tolerance & Therapeutic Frontiers
Addiction — now formally termed substance use disorder (SUD, DSM-5) — is a chronic, relapsing brain disorder characterized by compulsive drug seeking despite harmful consequences, affecting approximately 35 million peopl
Y_1_10 — Ibogaine: African Plant Medicine and Addiction Interruption
Ibogaine is a naturally occurring psychoactive indole alkaloid derived from the root bark of the West African shrub Tabernanthe iboga, which has been used for centuries in the Bwiti spiritual tradition of Gabon, Cameroon
H_4_29 — Food Industry Science Suppression
The systematic influence of the food industry on nutrition science, dietary guidelines, and public health policy represents one of the most extensively documented cases of corporate science suppression in the modern era
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