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15 results for "opioid"

Y_1_12 — Salvia Divinorum: Mazatec Sage and Kappa-Opioid Visionary

Salvia divinorum ("diviner's sage") is a psychoactive plant of the mint family (Lamiaceae) native to the cloud forests of the Sierra Mazateca in Oaxaca, Mexico, where it has been used for centuries by Mazatec healers and

Salvia divinorum salvinorin A kappa-opioid receptor Mazatec divination sage

X_2_13 Verified Medicine & Healing

X_2_13 — Pain Science: Nociception, Perception, and the Biopsychosocial Model

Pain is one of the most universal human experiences — and one of the most complex phenomena in medicine and neuroscience. The International Association for the Study of Pain (IASP) defines pain as "an unpleasant sensory

pain nociception chronic pain gate control theory Melzack Wall

X_4_15 Verified Medicine & Healing

X_4_15 — Addiction Medicine & Substance Abuse

Addiction medicine is a medical subspecialty formally recognised by the American Board of Medical Specialties (ABMS) in October 2015, though its intellectual roots stretch to Dr. Benjamin Rush's 1784 description of alcoh

addiction medicine substance use disorder opioid epidemic harm reduction mesolimbic pathway dopamine

X_3_09 Verified Medicine & Healing

X_3_09 — Anesthesia and Pain Management

Anesthesia and pain management — the medical control of pain and consciousness — revolutionized surgery and transformed the human experience of medical care. Before anesthesia, surgery was an ordeal of extreme suffering

anesthesia ether chloroform pain management analgesic opioid

X_3_29 Verified Medicine & Healing

X_3_29 — Pain Neuroscience: Gate Theory & Beyond

Pain neuroscience has undergone a revolution since the mid-twentieth century, transforming our understanding from a simple hardwired alarm system to a dynamic, modifiable experience shaped by neural circuits, cognition,

pain gate control theory Ronald Melzack Patrick Wall nociception central sensitization

Z_2_12 Molecular Biology

Z_2_12 — Genetics of Pain Perception

Pain perception — the subjective experience triggered by actual or potential tissue damage — varies enormously across individuals, with genetic factors accounting for 25–50% of the variance in pain sensitivity (twin stud

pain genetics nociception SCN9A Nav1.7 congenital insensitivity to pain TRPV1

K_5_02 Consciousness

K_5_02 — Pain, Consciousness, and the Nature of Suffering

Pain is one of the most philosophically revealing phenomena in consciousness studies: it is simultaneously a sensory detection system, an emotional experience, a cognitive evaluation, and a social communication — and the

pain consciousness suffering neuroscience pain matrix neuromatrix theory Melzack gate control affective pain

Credible

INTERDOC_23 — Placebo, Nocebo, and the Biology of Belief

[KEY FINDING] The placebo effect is not "fake medicine" — it involves genuine, measurable physiological changes mediated by endogenous neurotransmitter systems. Fabrizio Benedetti (University of Turin) has demonstrated:

placebo effect nocebo effect belief expectation endogenous opioids dopamine

T_2_07 Psychology & Social

T_2_07 — Psychology of Addiction

Addiction — compulsive engagement with a substance or behavior despite harmful consequences — is now understood as a chronic brain disorder involving neuroplastic changes in reward, motivation, memory, and executive cont

addiction psychology substance use disorder dopamine reward incentive sensitization tolerance dependence

Y_4_12 Verified Altered States

Y_4_12 — Psychosomatic Phenomena and the Placebo Effect

Psychosomatic phenomena — bodily changes produced by mental states — and the placebo effect — measurable physiological improvements following inert treatment — demonstrate that consciousness and belief can directly affec

placebo effect nocebo effect psychosomatic mind-body expectation conditioning

Y_5_07 Verified Altered States

Y_5_07 — Phenomenology of Pain and Pain Modulation

Pain — defined by the International Association for the Study of Pain (IASP, revised 2020) as "an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissu

pain nociception pain modulation gate control theory Melzack Wall

Y_1_19 Credible Altered States

Y_1_19 — Ibogaine Reset Mechanism

Ibogaine — a naturally occurring psychoactive indole alkaloid extracted from the root bark of Tabernanthe iboga, a shrub native to the equatorial forests of Gabon and Cameroon — has emerged as one of the most pharmacolog

ibogaine iboga Tabernanthe iboga addiction opioid noribogaine

Y_1_18 Verified Altered States

Y_1_18 — Addiction Neurochemistry: Reward Circuits, Tolerance & Therapeutic Frontiers

Addiction — now formally termed substance use disorder (SUD, DSM-5) — is a chronic, relapsing brain disorder characterized by compulsive drug seeking despite harmful consequences, affecting approximately 35 million peopl

addiction neurochemistry dopamine-reward mesolimbic-pathway opioid-crisis tolerance-dependence

Y_1_10 Credible Altered States

Y_1_10 — Ibogaine: African Plant Medicine and Addiction Interruption

Ibogaine is a naturally occurring psychoactive indole alkaloid derived from the root bark of the West African shrub Tabernanthe iboga, which has been used for centuries in the Bwiti spiritual tradition of Gabon, Cameroon

ibogaine iboga Tabernanthe iboga Bwiti addiction interruption opioid withdrawal

H_4_10 Verified Suppression & Thesis

H_4_10 — Corporate Suppression of Science

One of the most systematic and consequential forms of knowledge suppression in the modern era is the deliberate corporate manufacture of scientific doubt to protect profitable but harmful products. The strategy was pione

corporate science suppression tobacco industry doubt leaded gasoline Ethyl Corporation sugar industry

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