RESEARCH BASE
Search 3,721 documents across 34 fields — every claim tier-rated by evidence
3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.
17 results for "open-label placebo"
INTERDOC_23 — Placebo, Nocebo, and the Biology of Belief
[KEY FINDING] The placebo effect is not "fake medicine" — it involves genuine, measurable physiological changes mediated by endogenous neurotransmitter systems. Fabrizio Benedetti (University of Turin) has demonstrated:
X_2_01 — Psychosomatic Medicine and Placebo Science
The placebo effect — measurable physiological change resulting from the belief or expectation of treatment rather than the treatment's pharmacological action — is among the most replicated and least understood phenomena
T_2_13 — Placebo and Nocebo Effects
The placebo effect — a measurable physiological or psychological improvement in response to an inert treatment — is one of the most robust and well-documented phenomena in medicine and psychology, while the nocebo effect
Y_4_12 — Psychosomatic Phenomena and the Placebo Effect
Psychosomatic phenomena — bodily changes produced by mental states — and the placebo effect — measurable physiological improvements following inert treatment — demonstrate that consciousness and belief can directly affec
X_1_11 — Homeopathy: History and Controversy
Homeopathy — a medical system founded by German physician Samuel Hahnemann (1755–1843) based on the principle of similia similibus curentur ("like cures like") — holds that substances causing symptoms in healthy people c
Mind_Body_Healing_Frontier
The scientific investigation of mind-body interactions has progressed from fringe speculation to a major research domain supported by institutional infrastructure (National Center for Complementary and Integrative Health
X_2_05 — Naturopathy and Integrative Medicine
Naturopathy — a system of medical practice emphasizing the body's innate healing capacity, natural remedies, and prevention — and integrative medicine — the combination of conventional and complementary approaches based
X_2_16 — Evidence-Based Medicine and Clinical Trials
Evidence-based medicine (EBM) — the systematic integration of the best available research evidence with clinical expertise and patient values to guide medical decision-making — was formalized as a paradigm by Gordon Guya
X_5_20 — Medical Regulation: Clinical Trials, Drug Safety, and the History of Oversight
Medical regulation — the system of laws, agencies, and protocols governing drug development, clinical trials, and medical device approval — evolved over centuries from virtually no oversight to the elaborate global frame
X_1_10 — Acupuncture and Meridian Theory
Acupuncture — the insertion of thin needles into specific points on the body to treat pain and disease — is one of the most widely practiced and scientifically studied forms of traditional medicine, yet remains among the
K_4_02 — Stigmata, Faith Healing, and Psychosomatic Phenomena
The human body can do things under the influence of belief that should not be physically possible according to conventional medical models. The placebo effect — a "sugar pill" producing measurable physiological changes —
K_5_02 — Pain, Consciousness, and the Nature of Suffering
Pain is one of the most philosophically revealing phenomena in consciousness studies: it is simultaneously a sensory detection system, an emotional experience, a cognitive evaluation, and a social communication — and the
K_5_20 — Psychoneuroimmunology: Mind-Body-Immune Connections
Psychoneuroimmunology (PNI) — the study of interactions between psychological processes, the nervous system, and immune function — has established that the mind directly influences immune defense and that immune activity
ZC_5_17 — Ritual Efficacy Mechanisms: How Ritual Produces Real-World Effects
Ritual — formalized, repetitive, symbolic action that is culturally prescribed and often marked as distinct from ordinary behavior — is a universal feature of human societies, found in religious ceremonies, civic commemo
ZC_4_04 — Medical Anthropology — Culture, Healing, and the Body
Medical anthropology — the study of how health, illness, healing, and the body are experienced, understood, and managed across cultures — is one of anthropology's most productive subfields, bridging biological and social
T_2_06 — Health Psychology and Stress
Health psychology investigates how psychological, behavioral, and social factors influence health, illness, and healthcare — integrating biological and psychosocial perspectives within the biopsychosocial model (Engel, 1
Y_1_15 — Micro-Dosing: Sub-Perceptual Psychedelic Use and Cognitive Effects
Micro-dosing — the practice of regularly consuming sub-perceptual doses (typically 1/10th to 1/20th of a standard recreational dose) of psychedelic substances, most commonly LSD (~10–20 micrograms) or psilocybin (~0.1–0.
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