RESEARCH BASE
Search 3,721 documents across 34 fields — every claim tier-rated by evidence
3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.
49 results for "malaria resistance" — page 1 of 3
R_2_14 — Recent Human Evolution: Lactase Persistence, Altitude Adaptation, and Malaria Resistance
Human evolution did not stop with the emergence of Homo sapiens ~300,000 years ago — natural selection has continued to shape human biology in response to agriculture, diet, disease, climate, and altitude, producing some
L_5_06 — Genetic Adaptation to Disease: Malaria, Plague, TB
Infectious disease has been the most powerful selective force on the human genome throughout history. Pathogens — particularly malaria, plague, tuberculosis, smallpox, and cholera — have killed more humans than all other
Z_2_07 — Genetics of Disease Resistance
Infectious disease has been the most powerful selective force shaping the human genome, leaving signatures across thousands of loci. The best-understood example is sickle cell disease (HbS, Glu6Val in HBB): heterozygous
X_3_25 — Antibiotic Resistance Crisis
Antimicrobial resistance (AMR) — the ability of microorganisms to survive exposure to drugs that once killed them — is one of the most serious threats to global public health in the twenty-first century. [KEY FINDING] A
X_3_05 — Antibiotics and Antimicrobial Resistance
Antibiotics — substances that kill or inhibit bacterial growth — represent one of the most transformative medical discoveries in human history, having saved an estimated 200 million+ lives since their introduction. Their
W_5_14 — Mapuche Civilization: Resistance, Cosmovision, and Araucanian Culture
The Mapuche ("People of the Land") — also historically known by the Spanish term Araucanians — are an indigenous people of south-central Chile and southwestern Argentina who achieved something nearly unique in the histor
Z_3_07 — Gene Drive Technology
Gene drives are genetic systems that bias their own inheritance to spread through a population at rates exceeding normal Mendelian expectations (~50% → ~99% transmission). Natural selfish genetic elements (transposons, m
M_1_03 — Iron Pillar of Delhi — Unexplained Corrosion Resistance
The Iron Pillar of Delhi is a 7.21-meter, 6.5-tonne wrought iron column standing in the Qutb Minar complex in Mehrauli, New Delhi, dating to approximately 402 CE during the Gupta dynasty — most likely commissioned by Cha
ZC_5_12 — Peasant Studies: Agrarian Change, Moral Economy, and Resistance
Peasant studies is an interdisciplinary field studying the economic, social, political, and cultural life of rural agricultural communities — peasantries — and the processes of agrarian change, resistance, and transforma
H_2_11 — Scientific Revolutions: Kuhn, Paradigm Shifts, and Resistance
Thomas Kuhn's The Structure of Scientific Revolutions (1962) fundamentally altered understanding of how science changes by arguing that scientific progress is not a smooth, cumulative accumulation of knowledge but rather
ZE_5_05 — Ethics of Civil Disobedience: Thoreau, Gandhi, King, and Nonviolent Resistance
Civil disobedience — the deliberate, public, nonviolent violation of law undertaken to protest injustice and appeal to the moral conscience of the community — occupies a distinctive position in political ethics. It is no
ZE_4_11 — Philosophy of Resistance: Civil Disobedience and Dissent
The philosophy of resistance — the ethical, political, and practical dimensions of civil disobedience, conscientious objection, nonviolent direct action, and revolutionary dissent — addresses one of the most fundamental
S_4_04 — Pandemic Risk — Ancient Plagues, Antibiotic Resistance, and Biosecurity
Pandemics have repeatedly reshaped human civilization, from the Plague of Justinian (541 CE, ~25-50 million dead, Yersinia pestis confirmed via ancient DNA) to the Black Death (1347-1353, killing 30-60% of Europe's popul
Z_3_13 — Horizontal Gene Transfer in Prokaryotes
Horizontal gene transfer (HGT) — the movement of genetic material between organisms outside of parent-to-offspring inheritance — is a dominant force shaping prokaryotic evolution, fundamentally challenging the traditiona
ZB_2_21 — Horizontal Gene Transfer & Microbial Evolution
Horizontal gene transfer (HGT) — also called lateral gene transfer (LGT) — is the transmission of genetic material between organisms by mechanisms other than parent-to-offspring (vertical) inheritance. HGT is the dominan
R_1_14 — Biofilms: Microbial Communities, Quorum Sensing, and Cooperation
Biofilms are structured communities of microorganisms — bacteria, archaea, fungi, and algae — attached to surfaces and embedded in a self-produced matrix of extracellular polymeric substances (EPS): polysaccharides, prot
M_4_01 — Suppressed Archaeological Discoveries
The concept of "suppressed archaeology" requires careful separation of (1) genuine academic conservatism that slows acceptance of new paradigms (real and documented), (2) documented cases of destruction/loss of archaeolo
X_5_08 — One Health: Human, Animal, and Environmental Health Interconnected
One Health is an integrated, multidisciplinary approach that recognizes that the health of humans, animals, and ecosystems is fundamentally interconnected. The concept — formalized in the early 21st century but building
X_4_12 — Tropical Medicine: Disease, Ecology, and Global Health in the Tropics
Tropical medicine is the branch of medicine concerned with diseases that are prevalent or unique to tropical and subtropical regions — particularly vector-borne diseases (malaria, dengue, yellow fever, Chagas disease, le
X_3_20 — Infectious Disease & Epidemiology
Infectious diseases have shaped human history more profoundly than any other biological force. The germ theory of disease, established by Louis Pasteur and Robert Koch in the 1860s–1880s, transformed medicine from specul
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