RESEARCH BASE
Search 3,721 documents across 34 fields — every claim tier-rated by evidence
3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.
10 results for "ketamine"
Y_1_17 — Ketamine Therapy and Dissociative Medicine
Ketamine — a dissociative anesthetic synthesized by Calvin Stevens at Parke-Davis in 1962 and first used clinically by Edward Domino and Guenter Corssen in 1966 — has emerged as a revolutionary treatment for treatment-re
Y_1_11 — Ketamine: Dissociative Anesthetic and Consciousness Explorer
Ketamine is a dissociative anesthetic — first synthesized by Calvin Stevens in 1962 and introduced into clinical use by Edward Domino and Guenter Corssen (1966) — that has undergone a remarkable transformation from battl
X_2_03 — Psychedelic Medicine: Clinical Evidence and Renaissance
The psychedelic renaissance — the resurgence of clinical research into psychedelic compounds after decades of prohibition — represents one of the most significant paradigm shifts in modern psychiatry. Psilocybin for trea
K_3_16 — Anesthesia and Consciousness: What Going Under Reveals
General anesthesia provides a unique experimental window into consciousness: the ability to reversibly abolish and restore awareness in a controlled clinical setting. Despite over 175 years of practice since William T.G.
K_3_04 — Anesthesia and Consciousness
General anesthesia — the reversible, drug-induced abolition of consciousness — is one of medicine's greatest achievements and, paradoxically, one of its least understood. Approximately 350 million surgical procedures per
T_2_17 — Depression & Mood Disorders
Major Depressive Disorder (MDD) affects an estimated 280 million people worldwide (WHO, 2023) and is the leading cause of disability globally. The neurobiological understanding of depression has undergone a paradigm shif
T_1_19 — Depression: Neurobiology, Treatment Evolution & Cultural Perspectives
Major depressive disorder (MDD) — affecting approximately 280 million people worldwide (WHO, 2021) and ranking as the leading cause of disability globally — is a heterogeneous condition whose neurobiology remains incompl
Y_2_05 — Near-Death Experiences: Cross-Cultural Analysis
Near-death experiences (NDEs) — profound subjective experiences occurring during clinical death, cardiac arrest, or perceived proximity to death — have been reported across virtually all cultures and historical periods.
Y_2_08 — Anesthesia, Consciousness, and Awareness
General anesthesia — the pharmacological induction of unconsciousness, amnesia, analgesia, and immobility — is one of the most profound alterations of consciousness that humans routinely produce, yet how anesthetics actu
Y_1_04 — Psychedelic Renaissance — Clinical Research and Consciousness
The psychedelic renaissance — a resurgence of rigorous scientific research on psychedelic substances after decades of prohibition — has produced some of the most significant findings in 21st-century psychiatry and consci
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