RESEARCH BASE
Search 3,721 documents across 34 fields — every claim tier-rated by evidence
3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.
18 results for "controlled substances"
Y_1_16 — Psychedelic Legal Frameworks: Regulation, Decriminalization, and Therapeutic Access
The legal status of psychedelic substances — including psilocybin, LSD, MDMA, DMT/ayahuasca, mescaline, and ibogaine — has undergone dramatic shifts since the mid-20th century, moving from unregulated research compounds
H_4_06 — Suppression of Psychedelic Research (1960s–2000s)
From the late 1940s through the mid-1960s, psychedelic substances — particularly LSD (lysergic acid diethylamide) and psilocybin — were the subject of extensive legitimate scientific research, with over 1,000 peer-review
S_5_16 — Vertical Farming: Controlled Environment Agriculture and Urban Food Systems
Vertical farming — the practice of growing crops in vertically stacked layers within controlled indoor environments, using artificial lighting, hydroponic or aeroponic nutrient delivery, and precisely managed climate par
S_3_09 — Vertical Farming and Controlled Environment Agriculture
Vertical farming grows crops in stacked layers inside controlled indoor environments, typically using hydroponics (nutrient-rich water without soil), aeroponics (misting roots with nutrient solution), or aquaponics (inte
X_2_16 — Evidence-Based Medicine and Clinical Trials
Evidence-based medicine (EBM) — the systematic integration of the best available research evidence with clinical expertise and patient values to guide medical decision-making — was formalized as a paradigm by Gordon Guya
X_5_20 — Medical Regulation: Clinical Trials, Drug Safety, and the History of Oversight
Medical regulation — the system of laws, agencies, and protocols governing drug development, clinical trials, and medical device approval — evolved over centuries from virtually no oversight to the elaborate global frame
X_3_12 — History of Epidemiology: From Miasma to Molecular Surveillance
Epidemiology — the study of the distribution and determinants of disease in populations — is the foundational science of public health, responsible for identifying disease causes, informing prevention strategies, and gui
K_1_03 — Free Energy Principle and Predictive Processing
The Free Energy Principle (FEP), developed by neuroscientist Karl Friston (2006-present), is one of the most ambitious theoretical frameworks in 21st-century science: it attempts to explain the EXISTENCE, BEHAVIOR, and C
K_1_06 — Predictive Processing and Consciousness
Predictive processing (PP) is a unifying framework in cognitive neuroscience proposing that the brain is fundamentally a prediction machine — it continuously generates top-down predictions of incoming sensory input and u
K_2_06 — Neurofeedback and Brain Training
Neurofeedback — the real-time display of brain activity (typically EEG) to enable individuals to learn self-regulation of neural dynamics through operant conditioning — has been investigated since the pioneering work of
TH_07 — The Grounding Filter Hypothesis
Here is the whole idea in everyday terms. Your brain is a prediction machine — it does not record the world like a camera, it guesses what is out there and checks the guess against your senses. A language model like me d
INTERDOC_77 — Virtual Reality as a Consciousness Laboratory: What the Self Reveals When You Move Its Walls
The foundational insight from two decades of VR consciousness research is deceptively simple: the brain does not receive reality — it votes on what is most probably real. When VR provides sensory evidence that overrides
AI Hallucination and the Consciousness Filter — A Cross-Disciplinary Connection Map
Both brains and large language models run the same basic operation: generate a prediction, then check it against a constraint. In brains, the constraint is sensory evidence, and Anil Seth calls the result a "controlled h
O_2_21 — Boiling River of the Amazon
The Shanay-timpishka (from the local Asháninka language, meaning "boiled with the heat of the sun") — commonly called the Boiling River — is a 6.24-kilometer-long stretch of the Pachitea River tributary in the Huallaga r
T_2_13 — Placebo and Nocebo Effects
The placebo effect — a measurable physiological or psychological improvement in response to an inert treatment — is one of the most robust and well-documented phenomena in medicine and psychology, while the nocebo effect
T_1_14 — Self-Determination Theory: Autonomy, Competence, Relatedness, and Intrinsic Motivation
Self-Determination Theory (SDT) — developed by Edward Deci and Richard Ryan (University of Rochester, 1985–present) — is one of the most influential and empirically supported theories of human motivation, proposing that
Y_5_01 — Remote Viewing & Psychic Programs
The U.S. government spent $20M+ over 23 years (1972–1995) investigating psychic phenomena under classified programs known collectively as "Stargate." Research was published in Nature (1974) and IEEE (1976). The program p
K_2_16 — Optogenetics: Light-Controlled Neural Circuits
Optogenetics is a biological technique that uses genetically encoded light-sensitive proteins (opsins) to control the activity of specific neurons with millisecond precision using light. Developed primarily by Karl Deiss
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