X_2_08 — Fasting — Medical Science and Sacred Tradition

Fasting — the deliberate abstention from food for defined periods — is simultaneously one of humanity's oldest sacred practices (observed in virtually every major religious tradition) and one of the most actively investi

Z_2_10 — Genetics of Aging and Progeria

Aging — the progressive decline in physiological function leading to increased vulnerability to disease and death — has a substantial genetic component: twin studies estimate heritability of human lifespan at ~25–30% (He

Z_2_14 — Genetics of Longevity and Blue Zones

The genetics of human longevity — why some individuals live past 100 while most do not — is a field where heritability is modest, effect sizes are small, and environmental factors dominate, yet several genetic pathways h

ZB_2_05 — Aging, Longevity, and the Biology of Death

Why do organisms age and die? This question — one of the oldest in human inquiry — has yielded remarkable molecular answers in recent decades. Leonard Hayflick's 1961 discovery that human cells have a finite replicative

Y_4_21 — Fasting-Induced Altered States

Fasting-induced altered states of consciousness — visionary experiences, euphoria, time distortion, dissociation, and mystical-type experiences produced by prolonged food deprivation — represent one of humanity's oldest

Y_5_10 — Extreme Fasting: Breatharian Claims, Autophagy, and Metabolic States

Extreme fasting — prolonged and severe caloric restriction or complete food abstinence — occupies a unique position at the intersection of contemplative/ascetic practice, metabolic science, and pseudoscientific extremism

R_3_14 — Evolution of Aging and Senescence

Aging — the progressive decline in physiological function and increase in mortality rate with time — is one of evolution's deepest puzzles: why would natural selection, which optimizes fitness, permit organisms to deteri

S_2_08 — Longevity Science: Senolytics, Telomeres, and Lifespan Extension

Longevity science — the systematic study of biological aging with the goal of extending human healthspan (years of healthy life) and potentially lifespan — has transformed from a fringe pursuit into a mainstream biomedic

S_2_20 — Longevity Science & Senolytics

Longevity science — also termed geroscience — aims to understand and intervene in the biological mechanisms of aging to extend human healthspan (years of healthy life) and potentially lifespan. The field has shifted from

S_2_05 — Longevity Research — The Science of Aging, Life Extension, and the Quest for Biological Immortality

Aging — the progressive decline in physiological function leading to increased vulnerability, disease, and death — has transitioned from an accepted inevitability to a legitimate target of biomedical intervention. The fi

ZA_4_25 — Caloric Theory: The Heat Fluid That Built Thermodynamics

Caloric theory held that heat is a self-repelling, weightless, indestructible fluid — calorique — that flows from hotter bodies to cooler ones and can be stored within matter. Formalized by Antoine-Laurent de Lavoisier i

InterDoc: Productive Fictions — Real Effects from Nonexistent Referents