RESEARCH BASE

Search 3,721 documents across 34 fields — every claim tier-rated by evidence

3,721 Documents 34 Sections 43,625 Citations 34,852 Keywords Indexed 4 Evidence Tiers

3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.

6 results for "amyloid"

Z_2_20 Verified Molecular Biology

Z_2_20 — Prion Molecular Biology

At the molecular level, prion diseases arise from the conversion of the normal cellular prion protein (PrPᶜ) into a misfolded, aggregation-prone conformer (PrPˢᶜ) through a process that remains one of the most extraordin

prion PrP protein misfolding amyloid conformational change PrPSc

Z_2_08 Verified Molecular Biology

Z_2_08 — Prion Genetics and Misfolded Proteins

Prions are infectious agents composed entirely of misfolded protein — the only known pathogen that contains no nucleic acid (no DNA, no RNA). The protein-only hypothesis (Stanley Prusiner, 1982 — Nobel Prize 1997) states

prion PRNP PrP PrPSc PrPC prion diseases

Z_2_17 Verified Molecular Biology

Z_2_17 — Prion Biology: Self-Propagating Protein Misfolding and Transmissible Encephalopathies

Prions — proteinaceous infectious particles lacking nucleic acid — represent a paradigm-shattering departure from the central dogma that biological information flows from DNA to RNA to protein. The protein-only hypothesi

prion PrPSc PrPC transmissible spongiform encephalopathy Stanley Prusiner mad cow disease

Z_4_18 Verified Molecular Biology

Z_4_18 — Protein Misfolding and Prion Diseases

Prion diseases — transmissible spongiform encephalopathies (TSEs) — are fatal neurodegenerative disorders caused by the misfolding and self-propagating aggregation of a normal cellular protein (PrPᶜ) into a pathological

prion protein-misfolding amyloid bse cjd mad-cow-disease

Y_4_08 Verified Altered States

Y_4_08 — Sleep Science — REM, NREM, and the Ancient Understanding of Sleep

Sleep science has undergone a revolution in the 21st century, fundamentally altering our understanding of why humans sleep. The landmark 2012 discovery of the glymphatic system by Maiken Nedergaard revealed that the brai

sleep REM NREM glymphatic system slow-wave sleep dreams

R_5_17 Verified Biology & Evolution

R_5_17 — Prion Biology and Ecology

Prions — infectious agents composed entirely of misfolded protein, devoid of nucleic acid — represent one of the most conceptually revolutionary discoveries in biology, fundamentally challenging the central dogma that ge

prion PrP transmissible spongiform encephalopathy TSE mad cow disease BSE

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A Foundations 112 Docs B Beings & Entities 114 Docs C Global Traditions 116 Docs D Sites & Artifacts 116 Docs E Cataclysms & Chronology 109 Docs F Lost Connections 111 Docs G Modern Frameworks 99 Docs H Suppression & Thesis 95 Docs I UAP Disclosure 87 Docs J Ancient Technology 103 Docs K Consciousness 105 Docs L Genetics & Origins 92 Docs M Forbidden Archaeology 103 Docs N Secret Societies 87 Docs O Earth Anomalies 108 Docs P Philosophy & Meaning 104 Docs Q Cosmology & Physics 100 Docs R Biology & Evolution 95 Docs S Future Technology 100 Docs T Psychology & Social 112 Docs U Art, Music & Culture 122 Docs V Mathematics & Information 87 Docs W World Civilizations 140 Docs X Medicine & Healing 126 Docs Y Altered States 108 Docs Z Molecular Biology 112 Docs ZA Physics & Quantum 117 Docs ZB Ecology & Biology 117 Docs ZC Social Science 111 Docs ZD Information & Computation 96 Docs ZE Ethics & Applied Philosophy 99 Docs ZF Oceanography 105 Docs ZG Linguistics & Communication 110 Docs ZH Archaeoastronomy 114 Docs