RESEARCH BASE

Search 3,721 documents across 34 fields — every claim tier-rated by evidence

3,721 Documents 34 Sections 43,625 Citations 34,852 Keywords Indexed 4 Evidence Tiers

3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.

5 results for "Stanley Prusiner"

Z_2_17 Verified Molecular Biology

Z_2_17 — Prion Biology: Self-Propagating Protein Misfolding and Transmissible Encephalopathies

Prions — proteinaceous infectious particles lacking nucleic acid — represent a paradigm-shattering departure from the central dogma that biological information flows from DNA to RNA to protein. The protein-only hypothesi

prion PrPSc PrPC transmissible spongiform encephalopathy Stanley Prusiner mad cow disease

Z_4_18 Verified Molecular Biology

Z_4_18 — Protein Misfolding and Prion Diseases

Prion diseases — transmissible spongiform encephalopathies (TSEs) — are fatal neurodegenerative disorders caused by the misfolding and self-propagating aggregation of a normal cellular protein (PrPᶜ) into a pathological

prion protein-misfolding amyloid bse cjd mad-cow-disease

R_5_17 Verified Biology & Evolution

R_5_17 — Prion Biology and Ecology

Prions — infectious agents composed entirely of misfolded protein, devoid of nucleic acid — represent one of the most conceptually revolutionary discoveries in biology, fundamentally challenging the central dogma that ge

prion PrP transmissible spongiform encephalopathy TSE mad cow disease BSE

Z_2_08 Verified Molecular Biology

Z_2_08 — Prion Genetics and Misfolded Proteins

Prions are infectious agents composed entirely of misfolded protein — the only known pathogen that contains no nucleic acid (no DNA, no RNA). The protein-only hypothesis (Stanley Prusiner, 1982 — Nobel Prize 1997) states

prion PRNP PrP PrPSc PrPC prion diseases

E_2_02 Verified Cataclysms & Chronology

E_2_02 — Toba Supervolcano and the 74,000 BP Genetic Bottleneck

Approximately 74,000 years ago, the Toba supervolcano on the island of Sumatra (modern Indonesia) produced the largest volcanic eruption in the last 2 million years: a VEI-8 (Volcanic Explosivity Index maximum) event tha

Toba supervolcano volcanic winter 74000 BP genetic bottleneck population crash

BROWSE BY SECTION — 3,721 documents across 34 fields

A Foundations 112 Docs B Beings & Entities 114 Docs C Global Traditions 116 Docs D Sites & Artifacts 116 Docs E Cataclysms & Chronology 109 Docs F Lost Connections 111 Docs G Modern Frameworks 99 Docs H Suppression & Thesis 95 Docs I UAP Disclosure 87 Docs J Ancient Technology 103 Docs K Consciousness 105 Docs L Genetics & Origins 92 Docs M Forbidden Archaeology 103 Docs N Secret Societies 87 Docs O Earth Anomalies 108 Docs P Philosophy & Meaning 104 Docs Q Cosmology & Physics 100 Docs R Biology & Evolution 95 Docs S Future Technology 100 Docs T Psychology & Social 112 Docs U Art, Music & Culture 122 Docs V Mathematics & Information 87 Docs W World Civilizations 140 Docs X Medicine & Healing 126 Docs Y Altered States 108 Docs Z Molecular Biology 112 Docs ZA Physics & Quantum 117 Docs ZB Ecology & Biology 117 Docs ZC Social Science 111 Docs ZD Information & Computation 96 Docs ZE Ethics & Applied Philosophy 99 Docs ZF Oceanography 105 Docs ZG Linguistics & Communication 110 Docs ZH Archaeoastronomy 114 Docs