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Search 3,721 documents across 34 fields — every claim tier-rated by evidence

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3,633 are the core, quality-scored corpus (34 lettered sections — see How We Work); the remaining 88 are cross-corpus synthesis documents (68 InterDocs, 12 Connections, 8 Theories) also indexed here.

2 results for "Spravato"

Y_1_17 Verified Altered States

Y_1_17 — Ketamine Therapy and Dissociative Medicine

Ketamine — a dissociative anesthetic synthesized by Calvin Stevens at Parke-Davis in 1962 and first used clinically by Edward Domino and Guenter Corssen in 1966 — has emerged as a revolutionary treatment for treatment-re

ketamine esketamine spravato depression treatment-resistant nmda-receptor

Y_1_11 Verified Altered States

Y_1_11 — Ketamine: Dissociative Anesthetic and Consciousness Explorer

Ketamine is a dissociative anesthetic — first synthesized by Calvin Stevens in 1962 and introduced into clinical use by Edward Domino and Guenter Corssen (1966) — that has undergone a remarkable transformation from battl

ketamine dissociative anesthetic K-hole NMDA antagonist depression esketamine

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